This is the readme for the model associated with the paper: Kim Y, Hsu CL, Cembrowski MS, Mensh BD, Spruston N (2015) Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons. Elife This model was adapted based on previously published models (as described in the paper). The neuron was reconstructed from a 55-day-old male rat. This model requires NEURON which is freely available at http://www.neuron.yale.edu. Usage: Auto-launch from modeldb or download and extract the model. Compile the mod files in fullMorphCaLTP8 subfolder with nrnivmodl (unix/linux) or mknrndll (mswin or max os x). Use "start.hoc" to start the program ("nrngui start.hoc" on unix/linux, double click start.hoc in windows explorer (mswin), or drag and drop start.hoc onto the nrngui icon (mac)). After the simulation runs for a couple of minutes you should see the following figures which are similar to those in figure 8 in the paper: Questions can be directed to Ching-Lung Hsu (hsuc at janelia.hhmi.org), Mark Cembrowski (cembrowskim at janelia.hhmi.org) or Nelson Spruston (sprustonn at janelia.hhmi.org). 20150830 New version supplied by Ching-Lung Hsu corrects typos and simplifies init.hoc to omit caimax.mod, caiPeaks.mod, and vmax.mod from model.