/* Created by Language version: 6.2.0 */ /* NOT VECTORIZED */ #include #include #include #include "scoplib_ansi.h" #undef PI #define nil 0 #include "md1redef.h" #include "section.h" #include "nrniv_mf.h" #include "md2redef.h" #if METHOD3 extern int _method3; #endif #if !NRNGPU #undef exp #define exp hoc_Exp extern double hoc_Exp(double); #endif #define _threadargscomma_ /**/ #define _threadargs_ /**/ #define _threadargsprotocomma_ /**/ #define _threadargsproto_ /**/ /*SUPPRESS 761*/ /*SUPPRESS 762*/ /*SUPPRESS 763*/ /*SUPPRESS 765*/ extern double *getarg(); static double *_p; static Datum *_ppvar; #define t nrn_threads->_t #define dt nrn_threads->_dt #define gbar _p[0] #define g _p[1] #define C1 _p[2] #define C2 _p[3] #define C3 _p[4] #define C4 _p[5] #define C5 _p[6] #define I1 _p[7] #define I2 _p[8] #define I3 _p[9] #define I4 _p[10] #define I5 _p[11] #define O _p[12] #define I6 _p[13] #define f01 _p[14] #define f02 _p[15] #define f03 _p[16] #define f04 _p[17] #define f0O _p[18] #define f11 _p[19] #define f12 _p[20] #define f13 _p[21] #define f14 _p[22] #define f1n _p[23] #define fi1 _p[24] #define fi2 _p[25] #define fi3 _p[26] #define fi4 _p[27] #define fi5 _p[28] #define fin _p[29] #define b01 _p[30] #define b02 _p[31] #define b03 _p[32] #define b04 _p[33] #define b0O _p[34] #define b11 _p[35] #define b12 _p[36] #define b13 _p[37] #define b14 _p[38] #define b1n _p[39] #define bi1 _p[40] #define bi2 _p[41] #define bi3 _p[42] #define bi4 _p[43] #define bi5 _p[44] #define bin _p[45] #define ena _p[46] #define ina _p[47] #define DC1 _p[48] #define DC2 _p[49] #define DC3 _p[50] #define DC4 _p[51] #define DC5 _p[52] #define DI1 _p[53] #define DI2 _p[54] #define DI3 _p[55] #define DI4 _p[56] #define DI5 _p[57] #define DO _p[58] #define DI6 _p[59] #define _g _p[60] #define _ion_ena *_ppvar[0]._pval #define _ion_ina *_ppvar[1]._pval #define _ion_dinadv *_ppvar[2]._pval #if MAC #if !defined(v) #define v _mlhv #endif #if !defined(h) #define h _mlhh #endif #endif #if defined(__cplusplus) extern "C" { #endif static int hoc_nrnpointerindex = -1; /* external NEURON variables */ extern double celsius; /* declaration of user functions */ static void _hoc_rates(void); static int _mechtype; extern void _nrn_cacheloop_reg(int, int); extern void hoc_register_prop_size(int, int, int); extern void hoc_register_limits(int, HocParmLimits*); extern void hoc_register_units(int, HocParmUnits*); extern void nrn_promote(Prop*, int, int); extern Memb_func* memb_func; extern void _nrn_setdata_reg(int, void(*)(Prop*)); static void _setdata(Prop* _prop) { _p = _prop->param; _ppvar = _prop->dparam; } static void _hoc_setdata() { Prop *_prop, *hoc_getdata_range(int); _prop = hoc_getdata_range(_mechtype); _setdata(_prop); hoc_retpushx(1.); } /* connect user functions to hoc names */ static VoidFunc hoc_intfunc[] = { "setdata_NaV", _hoc_setdata, "rates_NaV", _hoc_rates, 0, 0 }; /* declare global and static user variables */ #define Coff Coff_NaV double Coff = 40; #define Con Con_NaV double Con = 0.01; #define Ooff Ooff_NaV double Ooff = 0.05; #define Oon Oon_NaV double Oon = 8; #define alfac alfac_NaV double alfac = 2.51; #define alpha alpha_NaV double alpha = 400; #define btfac btfac_NaV double btfac = 5.32; #define beta beta_NaV double beta = 12; #define delta delta_NaV double delta = 60; #define gamma gamma_NaV double gamma = 250; #define x2 x2_NaV double x2 = -24; #define x1 x1_NaV double x1 = 24; /* some parameters have upper and lower limits */ static HocParmLimits _hoc_parm_limits[] = { 0,0,0 }; static HocParmUnits _hoc_parm_units[] = { "Con_NaV", "/ms", "Coff_NaV", "/ms", "Oon_NaV", "/ms", "Ooff_NaV", "/ms", "alpha_NaV", "/ms", "beta_NaV", "/ms", "gamma_NaV", "/ms", "delta_NaV", "/ms", "x1_NaV", "mV", "x2_NaV", "mV", "gbar_NaV", "S/cm2", "g_NaV", "S/cm2", 0,0 }; static double C50 = 0; static double C40 = 0; static double C30 = 0; static double C20 = 0; static double C10 = 0; static double I60 = 0; static double I50 = 0; static double I40 = 0; static double I30 = 0; static double I20 = 0; static double I10 = 0; static double O0 = 0; static double delta_t = 0.01; static double v = 0; /* connect global user variables to hoc */ static DoubScal hoc_scdoub[] = { "Con_NaV", &Con_NaV, "Coff_NaV", &Coff_NaV, "Oon_NaV", &Oon_NaV, "Ooff_NaV", &Ooff_NaV, "alpha_NaV", &alpha_NaV, "beta_NaV", &beta_NaV, "gamma_NaV", &gamma_NaV, "delta_NaV", &delta_NaV, "alfac_NaV", &alfac_NaV, "btfac_NaV", &btfac_NaV, "x1_NaV", &x1_NaV, "x2_NaV", &x2_NaV, 0,0 }; static DoubVec hoc_vdoub[] = { 0,0,0 }; static double _sav_indep; static void nrn_alloc(Prop*); static void nrn_init(_NrnThread*, _Memb_list*, int); static void nrn_state(_NrnThread*, _Memb_list*, int); static void nrn_cur(_NrnThread*, _Memb_list*, int); static void nrn_jacob(_NrnThread*, _Memb_list*, int); static int _ode_count(int); static void _ode_map(int, double**, double**, double*, Datum*, double*, int); static void _ode_spec(_NrnThread*, _Memb_list*, int); static void _ode_matsol(_NrnThread*, _Memb_list*, int); #define _cvode_ieq _ppvar[3]._i /* connect range variables in _p that hoc is supposed to know about */ static const char *_mechanism[] = { "6.2.0", "NaV", "gbar_NaV", 0, "g_NaV", 0, "C1_NaV", "C2_NaV", "C3_NaV", "C4_NaV", "C5_NaV", "I1_NaV", "I2_NaV", "I3_NaV", "I4_NaV", "I5_NaV", "O_NaV", "I6_NaV", 0, 0}; static Symbol* _na_sym; extern Prop* need_memb(Symbol*); static void nrn_alloc(Prop* _prop) { Prop *prop_ion; double *_p; Datum *_ppvar; _p = nrn_prop_data_alloc(_mechtype, 61, _prop); /*initialize range parameters*/ gbar = 0.015; _prop->param = _p; _prop->param_size = 61; _ppvar = nrn_prop_datum_alloc(_mechtype, 4, _prop); _prop->dparam = _ppvar; /*connect ionic variables to this model*/ prop_ion = need_memb(_na_sym); nrn_promote(prop_ion, 0, 1); _ppvar[0]._pval = &prop_ion->param[0]; /* ena */ _ppvar[1]._pval = &prop_ion->param[3]; /* ina */ _ppvar[2]._pval = &prop_ion->param[4]; /* _ion_dinadv */ } static void _initlists(); /* some states have an absolute tolerance */ static Symbol** _atollist; static HocStateTolerance _hoc_state_tol[] = { 0,0 }; static void _update_ion_pointer(Datum*); extern Symbol* hoc_lookup(const char*); extern void _nrn_thread_reg(int, int, void(*f)(Datum*)); extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int)); extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***); extern void _cvode_abstol( Symbol**, double*, int); void _NaV_reg() { int _vectorized = 0; _initlists(); ion_reg("na", -10000.); _na_sym = hoc_lookup("na_ion"); register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 0); _mechtype = nrn_get_mechtype(_mechanism[1]); _nrn_setdata_reg(_mechtype, _setdata); _nrn_thread_reg(_mechtype, 2, _update_ion_pointer); hoc_register_prop_size(_mechtype, 61, 4); hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol); hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist); hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc); ivoc_help("help ?1 NaV /home/ramcdougal/temp/abi3/models/473561660/x86_64/NaV.mod\n"); hoc_register_limits(_mechtype, _hoc_parm_limits); hoc_register_units(_mechtype, _hoc_parm_units); } static int _reset; static char *modelname = "Mouse sodium current"; static int error; static int _ninits = 0; static int _match_recurse=1; static void _modl_cleanup(){ _match_recurse=1;} static int rates(double); extern double *_getelm(); #define _MATELM1(_row,_col) *(_getelm(_row + 1, _col + 1)) #define _RHS1(_arg) _coef1[_arg + 1] static double *_coef1; #define _linmat1 1 static void* _sparseobj1; static void* _cvsparseobj1; static int _ode_spec1(_threadargsproto_); /*static int _ode_matsol1(_threadargsproto_);*/ #define _RHS2(arg) _coef2[arg][12] static int _slist2[12];static double **_coef2; static void seqinitial(); static int _slist1[12], _dlist1[12]; static double *_temp1; static int activation(); static int activation () {_reset=0; { double b_flux, f_flux, _term; int _i; {int _i; double _dt1 = 1.0/dt; for(_i=1;_i<12;_i++){ _RHS1(_i) = -_dt1*(_p[_slist1[_i]] - _p[_dlist1[_i]]); _MATELM1(_i, _i) = _dt1; } } rates ( _threadargscomma_ v ) ; /* ~ C1 <-> C2 ( f01 , b01 )*/ f_flux = f01 * C1 ; b_flux = b01 * C2 ; _RHS1( 5) -= (f_flux - b_flux); _RHS1( 4) += (f_flux - b_flux); _term = f01 ; _MATELM1( 5 ,5) += _term; _MATELM1( 4 ,5) -= _term; _term = b01 ; _MATELM1( 5 ,4) -= _term; _MATELM1( 4 ,4) += _term; /*REACTION*/ /* ~ C2 <-> C3 ( f02 , b02 )*/ f_flux = f02 * C2 ; b_flux = b02 * C3 ; _RHS1( 4) -= (f_flux - b_flux); _RHS1( 3) += (f_flux - b_flux); _term = f02 ; _MATELM1( 4 ,4) += _term; _MATELM1( 3 ,4) -= _term; _term = b02 ; _MATELM1( 4 ,3) -= _term; _MATELM1( 3 ,3) += _term; /*REACTION*/ /* ~ C3 <-> C4 ( f03 , b03 )*/ f_flux = f03 * C3 ; b_flux = b03 * C4 ; _RHS1( 3) -= (f_flux - b_flux); _RHS1( 2) += (f_flux - b_flux); _term = f03 ; _MATELM1( 3 ,3) += _term; _MATELM1( 2 ,3) -= _term; _term = b03 ; _MATELM1( 3 ,2) -= _term; _MATELM1( 2 ,2) += _term; /*REACTION*/ /* ~ C4 <-> C5 ( f04 , b04 )*/ f_flux = f04 * C4 ; b_flux = b04 * C5 ; _RHS1( 2) -= (f_flux - b_flux); _RHS1( 1) += (f_flux - b_flux); _term = f04 ; _MATELM1( 2 ,2) += _term; _MATELM1( 1 ,2) -= _term; _term = b04 ; _MATELM1( 2 ,1) -= _term; _MATELM1( 1 ,1) += _term; /*REACTION*/ /* ~ C5 <-> O ( f0O , b0O )*/ f_flux = f0O * C5 ; b_flux = b0O * O ; _RHS1( 1) -= (f_flux - b_flux); _RHS1( 11) += (f_flux - b_flux); _term = f0O ; _MATELM1( 1 ,1) += _term; _MATELM1( 11 ,1) -= _term; _term = b0O ; _MATELM1( 1 ,11) -= _term; _MATELM1( 11 ,11) += _term; /*REACTION*/ /* ~ O <-> I6 ( fin , bin )*/ f_flux = fin * O ; b_flux = bin * I6 ; _RHS1( 11) -= (f_flux - b_flux); _term = fin ; _MATELM1( 11 ,11) += _term; _term = bin ; _MATELM1( 11 ,0) -= _term; /*REACTION*/ /* ~ I1 <-> I2 ( f11 , b11 )*/ f_flux = f11 * I1 ; b_flux = b11 * I2 ; _RHS1( 10) -= (f_flux - b_flux); _RHS1( 9) += (f_flux - b_flux); _term = f11 ; _MATELM1( 10 ,10) += _term; _MATELM1( 9 ,10) -= _term; _term = b11 ; _MATELM1( 10 ,9) -= _term; _MATELM1( 9 ,9) += _term; /*REACTION*/ /* ~ I2 <-> I3 ( f12 , b12 )*/ f_flux = f12 * I2 ; b_flux = b12 * I3 ; _RHS1( 9) -= (f_flux - b_flux); _RHS1( 8) += (f_flux - b_flux); _term = f12 ; _MATELM1( 9 ,9) += _term; _MATELM1( 8 ,9) -= _term; _term = b12 ; _MATELM1( 9 ,8) -= _term; _MATELM1( 8 ,8) += _term; /*REACTION*/ /* ~ I3 <-> I4 ( f13 , b13 )*/ f_flux = f13 * I3 ; b_flux = b13 * I4 ; _RHS1( 8) -= (f_flux - b_flux); _RHS1( 7) += (f_flux - b_flux); _term = f13 ; _MATELM1( 8 ,8) += _term; _MATELM1( 7 ,8) -= _term; _term = b13 ; _MATELM1( 8 ,7) -= _term; _MATELM1( 7 ,7) += _term; /*REACTION*/ /* ~ I4 <-> I5 ( f14 , b14 )*/ f_flux = f14 * I4 ; b_flux = b14 * I5 ; _RHS1( 7) -= (f_flux - b_flux); _RHS1( 6) += (f_flux - b_flux); _term = f14 ; _MATELM1( 7 ,7) += _term; _MATELM1( 6 ,7) -= _term; _term = b14 ; _MATELM1( 7 ,6) -= _term; _MATELM1( 6 ,6) += _term; /*REACTION*/ /* ~ I5 <-> I6 ( f1n , b1n )*/ f_flux = f1n * I5 ; b_flux = b1n * I6 ; _RHS1( 6) -= (f_flux - b_flux); _term = f1n ; _MATELM1( 6 ,6) += _term; _term = b1n ; _MATELM1( 6 ,0) -= _term; /*REACTION*/ /* ~ C1 <-> I1 ( fi1 , bi1 )*/ f_flux = fi1 * C1 ; b_flux = bi1 * I1 ; _RHS1( 5) -= (f_flux - b_flux); _RHS1( 10) += (f_flux - b_flux); _term = fi1 ; _MATELM1( 5 ,5) += _term; _MATELM1( 10 ,5) -= _term; _term = bi1 ; _MATELM1( 5 ,10) -= _term; _MATELM1( 10 ,10) += _term; /*REACTION*/ /* ~ C2 <-> I2 ( fi2 , bi2 )*/ f_flux = fi2 * C2 ; b_flux = bi2 * I2 ; _RHS1( 4) -= (f_flux - b_flux); _RHS1( 9) += (f_flux - b_flux); _term = fi2 ; _MATELM1( 4 ,4) += _term; _MATELM1( 9 ,4) -= _term; _term = bi2 ; _MATELM1( 4 ,9) -= _term; _MATELM1( 9 ,9) += _term; /*REACTION*/ /* ~ C3 <-> I3 ( fi3 , bi3 )*/ f_flux = fi3 * C3 ; b_flux = bi3 * I3 ; _RHS1( 3) -= (f_flux - b_flux); _RHS1( 8) += (f_flux - b_flux); _term = fi3 ; _MATELM1( 3 ,3) += _term; _MATELM1( 8 ,3) -= _term; _term = bi3 ; _MATELM1( 3 ,8) -= _term; _MATELM1( 8 ,8) += _term; /*REACTION*/ /* ~ C4 <-> I4 ( fi4 , bi4 )*/ f_flux = fi4 * C4 ; b_flux = bi4 * I4 ; _RHS1( 2) -= (f_flux - b_flux); _RHS1( 7) += (f_flux - b_flux); _term = fi4 ; _MATELM1( 2 ,2) += _term; _MATELM1( 7 ,2) -= _term; _term = bi4 ; _MATELM1( 2 ,7) -= _term; _MATELM1( 7 ,7) += _term; /*REACTION*/ /* ~ C5 <-> I5 ( fi5 , bi5 )*/ f_flux = fi5 * C5 ; b_flux = bi5 * I5 ; _RHS1( 1) -= (f_flux - b_flux); _RHS1( 6) += (f_flux - b_flux); _term = fi5 ; _MATELM1( 1 ,1) += _term; _MATELM1( 6 ,1) -= _term; _term = bi5 ; _MATELM1( 1 ,6) -= _term; _MATELM1( 6 ,6) += _term; /*REACTION*/ /* C1 + C2 + C3 + C4 + C5 + O + I1 + I2 + I3 + I4 + I5 + I6 = 1.0 */ _RHS1(0) = 1.0; _MATELM1(0, 0) = 1; _RHS1(0) -= I6 ; _MATELM1(0, 6) = 1; _RHS1(0) -= I5 ; _MATELM1(0, 7) = 1; _RHS1(0) -= I4 ; _MATELM1(0, 8) = 1; _RHS1(0) -= I3 ; _MATELM1(0, 9) = 1; _RHS1(0) -= I2 ; _MATELM1(0, 10) = 1; _RHS1(0) -= I1 ; _MATELM1(0, 11) = 1; _RHS1(0) -= O ; _MATELM1(0, 1) = 1; _RHS1(0) -= C5 ; _MATELM1(0, 2) = 1; _RHS1(0) -= C4 ; _MATELM1(0, 3) = 1; _RHS1(0) -= C3 ; _MATELM1(0, 4) = 1; _RHS1(0) -= C2 ; _MATELM1(0, 5) = 1; _RHS1(0) -= C1 ; /*CONSERVATION*/ } return _reset; } static void seqinitial () { zero_matrix(_coef2, 12, 13); { int _counte = -1; ++_counte; _coef2[_counte][0] -= 1.0 * bi1 ; _coef2[_counte][1] -= 1.0 * b01 ; _coef2[_counte][2] += 1.0 * ( fi1 + f01 ) ; _RHS2(_counte) -= 0.0 ; ; ++_counte; _coef2[_counte][2] -= 1.0 * f01 ; _coef2[_counte][3] -= 1.0 * bi2 ; _coef2[_counte][4] -= 1.0 * b02 ; _coef2[_counte][1] += 1.0 * ( b01 + fi2 + f02 ) ; _RHS2(_counte) -= 0.0 ; ; ++_counte; _coef2[_counte][1] -= 1.0 * f02 ; _coef2[_counte][5] -= 1.0 * bi3 ; _coef2[_counte][6] -= 1.0 * b03 ; _coef2[_counte][4] += 1.0 * ( b02 + fi3 + f03 ) ; _RHS2(_counte) -= 0.0 ; ; ++_counte; _coef2[_counte][4] -= 1.0 * f03 ; _coef2[_counte][7] -= 1.0 * bi4 ; _coef2[_counte][8] -= 1.0 * b04 ; _coef2[_counte][6] += 1.0 * ( b03 + fi4 + f04 ) ; _RHS2(_counte) -= 0.0 ; ; ++_counte; _coef2[_counte][6] -= 1.0 * f04 ; _coef2[_counte][9] -= 1.0 * bi5 ; _coef2[_counte][10] -= 1.0 * b0O ; _coef2[_counte][8] += 1.0 * ( b04 + fi5 + f0O ) ; _RHS2(_counte) -= 0.0 ; ; ++_counte; _coef2[_counte][8] -= 1.0 * f0O ; _coef2[_counte][11] -= 1.0 * bin ; _coef2[_counte][10] += 1.0 * ( b0O + fin ) ; _RHS2(_counte) -= 0.0 ; ; ++_counte; _coef2[_counte][2] -= 1.0 * fi1 ; _coef2[_counte][3] -= 1.0 * b11 ; _coef2[_counte][0] += 1.0 * ( bi1 + f11 ) ; _RHS2(_counte) -= 0.0 ; ; ++_counte; _coef2[_counte][0] -= 1.0 * f11 ; _coef2[_counte][1] -= 1.0 * fi2 ; _coef2[_counte][5] -= 1.0 * b12 ; _coef2[_counte][3] += 1.0 * ( b11 + bi2 + f12 ) ; _RHS2(_counte) -= 0.0 ; ; ++_counte; _coef2[_counte][3] -= 1.0 * f12 ; _coef2[_counte][4] -= 1.0 * fi3 ; _coef2[_counte][7] -= 1.0 * bi3 ; _coef2[_counte][5] += 1.0 * ( b12 + bi3 + f13 ) ; _RHS2(_counte) -= 0.0 ; ; ++_counte; _coef2[_counte][5] -= 1.0 * f13 ; _coef2[_counte][6] -= 1.0 * fi4 ; _coef2[_counte][9] -= 1.0 * b14 ; _coef2[_counte][7] += 1.0 * ( b13 + bi4 + f14 ) ; _RHS2(_counte) -= 0.0 ; ; ++_counte; _coef2[_counte][7] -= 1.0 * f14 ; _coef2[_counte][8] -= 1.0 * fi5 ; _coef2[_counte][11] -= 1.0 * b1n ; _coef2[_counte][9] += 1.0 * ( b14 + bi5 + f1n ) ; _RHS2(_counte) -= 0.0 ; ; ++_counte; _coef2[_counte][2] -= 1.0 ; _coef2[_counte][1] -= 1.0 ; _coef2[_counte][4] -= 1.0 ; _coef2[_counte][6] -= 1.0 ; _coef2[_counte][8] -= 1.0 ; _coef2[_counte][10] -= 1.0 ; _coef2[_counte][0] -= 1.0 ; _coef2[_counte][3] -= 1.0 ; _coef2[_counte][5] -= 1.0 ; _coef2[_counte][7] -= 1.0 ; _coef2[_counte][9] -= 1.0 ; _coef2[_counte][11] -= 1.0 ; _RHS2(_counte) -= 1.0 ; ; } } static int rates ( double _lv ) { double _lqt ; _lqt = pow( 2.3 , ( ( celsius - 37.0 ) / 10.0 ) ) ; f01 = _lqt * 4.0 * alpha * exp ( _lv / x1 ) ; f02 = _lqt * 3.0 * alpha * exp ( _lv / x1 ) ; f03 = _lqt * 2.0 * alpha * exp ( _lv / x1 ) ; f04 = _lqt * 1.0 * alpha * exp ( _lv / x1 ) ; f0O = _lqt * gamma ; f11 = _lqt * 4.0 * alpha * alfac * exp ( _lv / x1 ) ; f12 = _lqt * 3.0 * alpha * alfac * exp ( _lv / x1 ) ; f13 = _lqt * 2.0 * alpha * alfac * exp ( _lv / x1 ) ; f14 = _lqt * 1.0 * alpha * alfac * exp ( _lv / x1 ) ; f1n = _lqt * gamma ; fi1 = _lqt * Con ; fi2 = _lqt * Con * alfac ; fi3 = _lqt * Con * pow( alfac , 2.0 ) ; fi4 = _lqt * Con * pow( alfac , 3.0 ) ; fi5 = _lqt * Con * pow( alfac , 4.0 ) ; fin = _lqt * Oon ; b01 = _lqt * 1.0 * beta * exp ( _lv / x2 ) ; b02 = _lqt * 2.0 * beta * exp ( _lv / x2 ) ; b03 = _lqt * 3.0 * beta * exp ( _lv / x2 ) ; b04 = _lqt * 4.0 * beta * exp ( _lv / x2 ) ; b0O = _lqt * delta ; b11 = _lqt * 1.0 * beta * exp ( _lv / x2 ) / btfac ; b12 = _lqt * 2.0 * beta * exp ( _lv / x2 ) / btfac ; b13 = _lqt * 3.0 * beta * exp ( _lv / x2 ) / btfac ; b14 = _lqt * 4.0 * beta * exp ( _lv / x2 ) / btfac ; b1n = _lqt * delta ; bi1 = _lqt * Coff ; bi2 = _lqt * Coff / ( btfac ) ; bi3 = _lqt * Coff / ( pow( btfac , 2.0 ) ) ; bi4 = _lqt * Coff / ( pow( btfac , 3.0 ) ) ; bi5 = _lqt * Coff / ( pow( btfac , 4.0 ) ) ; bin = _lqt * Ooff ; return 0; } static void _hoc_rates(void) { double _r; _r = 1.; rates ( *getarg(1) ); hoc_retpushx(_r); } /*CVODE ode begin*/ static int _ode_spec1() {_reset=0;{ double b_flux, f_flux, _term; int _i; {int _i; for(_i=0;_i<12;_i++) _p[_dlist1[_i]] = 0.0;} rates ( _threadargscomma_ v ) ; /* ~ C1 <-> C2 ( f01 , b01 )*/ f_flux = f01 * C1 ; b_flux = b01 * C2 ; DC1 -= (f_flux - b_flux); DC2 += (f_flux - b_flux); /*REACTION*/ /* ~ C2 <-> C3 ( f02 , b02 )*/ f_flux = f02 * C2 ; b_flux = b02 * C3 ; DC2 -= (f_flux - b_flux); DC3 += (f_flux - b_flux); /*REACTION*/ /* ~ C3 <-> C4 ( f03 , b03 )*/ f_flux = f03 * C3 ; b_flux = b03 * C4 ; DC3 -= (f_flux - b_flux); DC4 += (f_flux - b_flux); /*REACTION*/ /* ~ C4 <-> C5 ( f04 , b04 )*/ f_flux = f04 * C4 ; b_flux = b04 * C5 ; DC4 -= (f_flux - b_flux); DC5 += (f_flux - b_flux); /*REACTION*/ /* ~ C5 <-> O ( f0O , b0O )*/ f_flux = f0O * C5 ; b_flux = b0O * O ; DC5 -= (f_flux - b_flux); DO += (f_flux - b_flux); /*REACTION*/ /* ~ O <-> I6 ( fin , bin )*/ f_flux = fin * O ; b_flux = bin * I6 ; DO -= (f_flux - b_flux); DI6 += (f_flux - b_flux); /*REACTION*/ /* ~ I1 <-> I2 ( f11 , b11 )*/ f_flux = f11 * I1 ; b_flux = b11 * I2 ; DI1 -= (f_flux - b_flux); DI2 += (f_flux - b_flux); /*REACTION*/ /* ~ I2 <-> I3 ( f12 , b12 )*/ f_flux = f12 * I2 ; b_flux = b12 * I3 ; DI2 -= (f_flux - b_flux); DI3 += (f_flux - b_flux); /*REACTION*/ /* ~ I3 <-> I4 ( f13 , b13 )*/ f_flux = f13 * I3 ; b_flux = b13 * I4 ; DI3 -= (f_flux - b_flux); DI4 += (f_flux - b_flux); /*REACTION*/ /* ~ I4 <-> I5 ( f14 , b14 )*/ f_flux = f14 * I4 ; b_flux = b14 * I5 ; DI4 -= (f_flux - b_flux); DI5 += (f_flux - b_flux); /*REACTION*/ /* ~ I5 <-> I6 ( f1n , b1n )*/ f_flux = f1n * I5 ; b_flux = b1n * I6 ; DI5 -= (f_flux - b_flux); DI6 += (f_flux - b_flux); /*REACTION*/ /* ~ C1 <-> I1 ( fi1 , bi1 )*/ f_flux = fi1 * C1 ; b_flux = bi1 * I1 ; DC1 -= (f_flux - b_flux); DI1 += (f_flux - b_flux); /*REACTION*/ /* ~ C2 <-> I2 ( fi2 , bi2 )*/ f_flux = fi2 * C2 ; b_flux = bi2 * I2 ; DC2 -= (f_flux - b_flux); DI2 += (f_flux - b_flux); /*REACTION*/ /* ~ C3 <-> I3 ( fi3 , bi3 )*/ f_flux = fi3 * C3 ; b_flux = bi3 * I3 ; DC3 -= (f_flux - b_flux); DI3 += (f_flux - b_flux); /*REACTION*/ /* ~ C4 <-> I4 ( fi4 , bi4 )*/ f_flux = fi4 * C4 ; b_flux = bi4 * I4 ; DC4 -= (f_flux - b_flux); DI4 += (f_flux - b_flux); /*REACTION*/ /* ~ C5 <-> I5 ( fi5 , bi5 )*/ f_flux = fi5 * C5 ; b_flux = bi5 * I5 ; DC5 -= (f_flux - b_flux); DI5 += (f_flux - b_flux); /*REACTION*/ /* C1 + C2 + C3 + C4 + C5 + O + I1 + I2 + I3 + I4 + I5 + I6 = 1.0 */ /*CONSERVATION*/ } return _reset; } /*CVODE matsol*/ static int _ode_matsol1() {_reset=0;{ double b_flux, f_flux, _term; int _i; b_flux = f_flux = 0.; {int _i; double _dt1 = 1.0/dt; for(_i=0;_i<12;_i++){ _RHS1(_i) = _dt1*(_p[_dlist1[_i]]); _MATELM1(_i, _i) = _dt1; } } rates ( _threadargscomma_ v ) ; /* ~ C1 <-> C2 ( f01 , b01 )*/ _term = f01 ; _MATELM1( 5 ,5) += _term; _MATELM1( 4 ,5) -= _term; _term = b01 ; _MATELM1( 5 ,4) -= _term; _MATELM1( 4 ,4) += _term; /*REACTION*/ /* ~ C2 <-> C3 ( f02 , b02 )*/ _term = f02 ; _MATELM1( 4 ,4) += _term; _MATELM1( 3 ,4) -= _term; _term = b02 ; _MATELM1( 4 ,3) -= _term; _MATELM1( 3 ,3) += _term; /*REACTION*/ /* ~ C3 <-> C4 ( f03 , b03 )*/ _term = f03 ; _MATELM1( 3 ,3) += _term; _MATELM1( 2 ,3) -= _term; _term = b03 ; _MATELM1( 3 ,2) -= _term; _MATELM1( 2 ,2) += _term; /*REACTION*/ /* ~ C4 <-> C5 ( f04 , b04 )*/ _term = f04 ; _MATELM1( 2 ,2) += _term; _MATELM1( 1 ,2) -= _term; _term = b04 ; _MATELM1( 2 ,1) -= _term; _MATELM1( 1 ,1) += _term; /*REACTION*/ /* ~ C5 <-> O ( f0O , b0O )*/ _term = f0O ; _MATELM1( 1 ,1) += _term; _MATELM1( 11 ,1) -= _term; _term = b0O ; _MATELM1( 1 ,11) -= _term; _MATELM1( 11 ,11) += _term; /*REACTION*/ /* ~ O <-> I6 ( fin , bin )*/ _term = fin ; _MATELM1( 11 ,11) += _term; _MATELM1( 0 ,11) -= _term; _term = bin ; _MATELM1( 11 ,0) -= _term; _MATELM1( 0 ,0) += _term; /*REACTION*/ /* ~ I1 <-> I2 ( f11 , b11 )*/ _term = f11 ; _MATELM1( 10 ,10) += _term; _MATELM1( 9 ,10) -= _term; _term = b11 ; _MATELM1( 10 ,9) -= _term; _MATELM1( 9 ,9) += _term; /*REACTION*/ /* ~ I2 <-> I3 ( f12 , b12 )*/ _term = f12 ; _MATELM1( 9 ,9) += _term; _MATELM1( 8 ,9) -= _term; _term = b12 ; _MATELM1( 9 ,8) -= _term; _MATELM1( 8 ,8) += _term; /*REACTION*/ /* ~ I3 <-> I4 ( f13 , b13 )*/ _term = f13 ; _MATELM1( 8 ,8) += _term; _MATELM1( 7 ,8) -= _term; _term = b13 ; _MATELM1( 8 ,7) -= _term; _MATELM1( 7 ,7) += _term; /*REACTION*/ /* ~ I4 <-> I5 ( f14 , b14 )*/ _term = f14 ; _MATELM1( 7 ,7) += _term; _MATELM1( 6 ,7) -= _term; _term = b14 ; _MATELM1( 7 ,6) -= _term; _MATELM1( 6 ,6) += _term; /*REACTION*/ /* ~ I5 <-> I6 ( f1n , b1n )*/ _term = f1n ; _MATELM1( 6 ,6) += _term; _MATELM1( 0 ,6) -= _term; _term = b1n ; _MATELM1( 6 ,0) -= _term; _MATELM1( 0 ,0) += _term; /*REACTION*/ /* ~ C1 <-> I1 ( fi1 , bi1 )*/ _term = fi1 ; _MATELM1( 5 ,5) += _term; _MATELM1( 10 ,5) -= _term; _term = bi1 ; _MATELM1( 5 ,10) -= _term; _MATELM1( 10 ,10) += _term; /*REACTION*/ /* ~ C2 <-> I2 ( fi2 , bi2 )*/ _term = fi2 ; _MATELM1( 4 ,4) += _term; _MATELM1( 9 ,4) -= _term; _term = bi2 ; _MATELM1( 4 ,9) -= _term; _MATELM1( 9 ,9) += _term; /*REACTION*/ /* ~ C3 <-> I3 ( fi3 , bi3 )*/ _term = fi3 ; _MATELM1( 3 ,3) += _term; _MATELM1( 8 ,3) -= _term; _term = bi3 ; _MATELM1( 3 ,8) -= _term; _MATELM1( 8 ,8) += _term; /*REACTION*/ /* ~ C4 <-> I4 ( fi4 , bi4 )*/ _term = fi4 ; _MATELM1( 2 ,2) += _term; _MATELM1( 7 ,2) -= _term; _term = bi4 ; _MATELM1( 2 ,7) -= _term; _MATELM1( 7 ,7) += _term; /*REACTION*/ /* ~ C5 <-> I5 ( fi5 , bi5 )*/ _term = fi5 ; _MATELM1( 1 ,1) += _term; _MATELM1( 6 ,1) -= _term; _term = bi5 ; _MATELM1( 1 ,6) -= _term; _MATELM1( 6 ,6) += _term; /*REACTION*/ /* C1 + C2 + C3 + C4 + C5 + O + I1 + I2 + I3 + I4 + I5 + I6 = 1.0 */ /*CONSERVATION*/ } return _reset; } /*CVODE end*/ static int _ode_count(int _type){ return 12;} static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) { Datum* _thread; Node* _nd; double _v; int _iml, _cntml; _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; _nd = _ml->_nodelist[_iml]; v = NODEV(_nd); ena = _ion_ena; _ode_spec1 (); }} static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) { int _i; _p = _pp; _ppvar = _ppd; _cvode_ieq = _ieq; for (_i=0; _i < 12; ++_i) { _pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i]; _cvode_abstol(_atollist, _atol, _i); } } static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) { Datum* _thread; Node* _nd; double _v; int _iml, _cntml; _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; _nd = _ml->_nodelist[_iml]; v = NODEV(_nd); ena = _ion_ena; _cvode_sparse(&_cvsparseobj1, 12, _dlist1, _p, _ode_matsol1, &_coef1); }} extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int); static void _update_ion_pointer(Datum* _ppvar) { nrn_update_ion_pointer(_na_sym, _ppvar, 0, 0); nrn_update_ion_pointer(_na_sym, _ppvar, 1, 3); nrn_update_ion_pointer(_na_sym, _ppvar, 2, 4); } static void initmodel() { int _i; double _save;_ninits++; _save = t; t = 0.0; { C5 = C50; C4 = C40; C3 = C30; C2 = C20; C1 = C10; I6 = I60; I5 = I50; I4 = I40; I3 = I30; I2 = I20; I1 = I10; O = O0; { rates ( _threadargscomma_ v ) ; error = 0; seqinitial(); error = simeq(12, _coef2, _p, _slist2); if(error){fprintf(stderr,"at line 104 in file NaV.mod:\n SOLVE seqinitial\n"); nrn_complain(_p); abort_run(error);} } _sav_indep = t; t = _save; } } static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){ Node *_nd; double _v; int* _ni; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; #if CACHEVEC if (use_cachevec) { _v = VEC_V(_ni[_iml]); }else #endif { _nd = _ml->_nodelist[_iml]; _v = NODEV(_nd); } v = _v; ena = _ion_ena; initmodel(); }} static double _nrn_current(double _v){double _current=0.;v=_v;{ { g = gbar * O ; ina = g * ( v - ena ) ; } _current += ina; } return _current; } static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type){ Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; #if CACHEVEC if (use_cachevec) { _v = VEC_V(_ni[_iml]); }else #endif { _nd = _ml->_nodelist[_iml]; _v = NODEV(_nd); } ena = _ion_ena; _g = _nrn_current(_v + .001); { double _dina; _dina = ina; _rhs = _nrn_current(_v); _ion_dinadv += (_dina - ina)/.001 ; } _g = (_g - _rhs)/.001; _ion_ina += ina ; #if CACHEVEC if (use_cachevec) { VEC_RHS(_ni[_iml]) -= _rhs; }else #endif { NODERHS(_nd) -= _rhs; } }} static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type){ Node *_nd; int* _ni; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; #if CACHEVEC if (use_cachevec) { VEC_D(_ni[_iml]) += _g; }else #endif { _nd = _ml->_nodelist[_iml]; NODED(_nd) += _g; } }} static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type){ double _break, _save; Node *_nd; double _v; int* _ni; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; _nd = _ml->_nodelist[_iml]; #if CACHEVEC if (use_cachevec) { _v = VEC_V(_ni[_iml]); }else #endif { _nd = _ml->_nodelist[_iml]; _v = NODEV(_nd); } _break = t + .5*dt; _save = t; v=_v; { ena = _ion_ena; { { for (; t < _break; t += dt) { error = sparse(&_sparseobj1, 12, _slist1, _dlist1, _p, &t, dt, activation,&_coef1, _linmat1); if(error){fprintf(stderr,"at line 97 in file NaV.mod:\n SOLVE activation METHOD sparse\n"); nrn_complain(_p); abort_run(error);} }} t = _save; } }} } static void terminal(){} static void _initlists() { int _i; static int _first = 1; if (!_first) return; _slist2[0] = &(I1) - _p; _slist2[1] = &(C2) - _p; _slist2[2] = &(C1) - _p; _slist2[3] = &(I2) - _p; _slist2[4] = &(C3) - _p; _slist2[5] = &(I3) - _p; _slist2[6] = &(C4) - _p; _slist2[7] = &(I4) - _p; _slist2[8] = &(C5) - _p; _slist2[9] = &(I5) - _p; _slist2[10] = &(O) - _p; _slist2[11] = &(I6) - _p; if (_first) _coef2 = makematrix(12, 13); _slist1[0] = &(I6) - _p; _dlist1[0] = &(DI6) - _p; _slist1[1] = &(C5) - _p; _dlist1[1] = &(DC5) - _p; _slist1[2] = &(C4) - _p; _dlist1[2] = &(DC4) - _p; _slist1[3] = &(C3) - _p; _dlist1[3] = &(DC3) - _p; _slist1[4] = &(C2) - _p; _dlist1[4] = &(DC2) - _p; _slist1[5] = &(C1) - _p; _dlist1[5] = &(DC1) - _p; _slist1[6] = &(I5) - _p; _dlist1[6] = &(DI5) - _p; _slist1[7] = &(I4) - _p; _dlist1[7] = &(DI4) - _p; _slist1[8] = &(I3) - _p; _dlist1[8] = &(DI3) - _p; _slist1[9] = &(I2) - _p; _dlist1[9] = &(DI2) - _p; _slist1[10] = &(I1) - _p; _dlist1[10] = &(DI1) - _p; _slist1[11] = &(O) - _p; _dlist1[11] = &(DO) - _p; _first = 0; }