celsius = 35 v_init=-70 global_ra=200.00 // internal resistivity in ohm-cm Cm=1.5 //0.75 // specific membrane capacitance in uF/cm^2 Cmy=0.075 // capacitance in myelin Rm=40000 // specific membrane resistivity in ohm-cm^2 Rn=50 // nodal resistivity Vleak=-46 // switched from -66, in order to give a proper resting potential Vrest=-70 // resting potential -60 in control, -66 in Cs+ spinelimit=100 // distance beyond which to modify for spines spinefactor=2.0 // factor by which to change passive properties setgk = .036 // A-type potassium starting density, used in init_bday.hoc setokslope = 0 // slope of A-type potassium conductance along individual oblique branches. set to 0 in all simulations gkdr=0.040 // delayed rectifier density gkap=setgk // proximal A-type potassium starting density gkad=setgk // distal A-type potassium starting density dlimit=300 // cut-off for increase of A-type density dprox=50 // distance to switch from proximal to distal type dslope=0.01 // slope of A-type density okslope = setokslope // oblique potassium channel gradient okmax = .5 // max potassium channel conductance ampaWeight = 0.00018 // in uS; 0.00018 used in Jarsky et al 2005 nmdaWeight = 0.00018 // in uS gnaSoma = 0.1 gnaSr = 0.03 gnaSlm = 0.03 // Inhibition parameters. inhRev = -75 npyTau1 = 0.1 npyTau2 = 10 sstTau1 = 0.2 // from Maccaferri et al., 2000 sstTau2 = 18 // from Maccaferri et al., 2000 npyWeight = 0.001 // from Maccaferri et al., 2000 sstWeight = 0.001 // from Maccaferri et al 2000