def getMT(): # List of genes # List of mutations # List of groups of variables # Pair (variable list + range) # List of variables MT = [] #CACNA1C: MT.append([ [ [ ['offm_cah', 'offmt_cah'], -25.9 ], #http://www.ncbi.nlm.nih.gov/pubmed/19265197 [ ['offh_cah', 'offht_cah'], -27.0 ] ], [ [ ['offm_cah', 'offht_cah'], -37.3 ], #http://www.ncbi.nlm.nih.gov/pubmed/19265197 [ ['offh_cah', 'offht_cah'], -30.0 ] ], [ [ ['offm_cah', 'offmt_cah'], [-31.4, +7.0] ], #http://www.ncbi.nlm.nih.gov/pubmed/21685391 [ ['slom_cah', 'slomt_cah'], [0.85, 1.45] ], [ ['offh_cah', 'offht_cah'], [-28.5, +16.3] ], [ ['sloh_cah', 'sloht_cah'], [0.72, 1.38] ] ], [ [ ['offm_cah', 'offmt_cah'], [-38.5, +12.9] ], #http://www.ncbi.nlm.nih.gov/pubmed/16157588 [ ['slom_cah', 'slomt_cah'], [0.46, 1.56] ] ], [ [ ['offm_cah', 'offmt_cah'], [-27.8, +8.7] ], #http://www.ncbi.nlm.nih.gov/pubmed/18836301 [ ['slom_cah', 'slomt_cah'], [0.89, 1.14] ], [ ['offh_cah', 'offht_cah'], [-19.1, +4.7] ] ], [ [ ['offm_cah', 'offmt_cah'], [-11.2, +1.0] ], #http://www.ncbi.nlm.nih.gov/pubmed/15299022 [ ['offh_cah', 'offht_cah'], -3.1 ], [ ['sloh_cah', 'sloht_cah'], 1.24 ] ] ]) #CACNB2: MT.append([ [ [ ['offh_cah', 'offht_cah'], -5.2 ], #http://www.ncbi.nlm.nih.gov/pubmed/19358333 [ ['sloh_cah', 'sloht_cah'], 0.69 ] ], [ [ 'tauhmax_cah', 1.7 ] ], #http://www.ncbi.nlm.nih.gov/pubmed/7723731 [ [ ['offm_cah', 'offmt_cah'], [-4.9, 4.9] ], #http://www.ncbi.nlm.nih.gov/pubmed/19723630 [ ['offh_cah', 'offht_cah'], [-5.1, 5.1] ], [ 'taummax_cah', [0.6, 1.68] ], [ 'tauhmax_cah', [0.6, 1.66] ] ], [ [ 'taummax_cah', 1.26] ] ]) #http://www.ncbi.nlm.nih.gov/pubmed/20025708 #CACNA1D: MT.append([ [ [ ['offm_cah', 'offmt_cah'], -10.9 ], #http://www.ncbi.nlm.nih.gov/pubmed/21998309 and [ ['slom_cah', 'slomt_cah'], 0.73 ], #http://www.ncbi.nlm.nih.gov/pubmed/21998310 [ ['offh_cah', 'offht_cah'], [-3.0, 3.5] ], #(42A) [ ['sloh_cah', 'sloht_cah'], 0.81 ], [ 'tauhmax_cah', 1.25 ] ], [ [ ['offm_cah', 'offmt_cah'], [-10.6, 3.4] ], #http://www.ncbi.nlm.nih.gov/pubmed/21998309 and [ ['slom_cah', 'slomt_cah'], [0.8, 1.12] ], #http://www.ncbi.nlm.nih.gov/pubmed/21998310 [ ['offh_cah', 'offht_cah'], [-5.3, 1.2] ], #(43S) [ ['sloh_cah', 'sloht_cah'], 0.66 ], [ 'tauhmax_cah', 0.72 ] ], [ [ ['offm_cah', 'offmt_cah'], 6.6 ], #http://www.ncbi.nlm.nih.gov/pubmed/20951705 and [ ['slom_cah', 'slomt_cah'], [0.75, 1.19] ], #http://www.ncbi.nlm.nih.gov/pubmed/21054386 [ 'tauhmax_cah', [0.5, 1.12] ] ], #(CaV1.3 KO) [ [ ['offm_cah', 'offmt_cah'], -9.8 ], #http://www.ncbi.nlm.nih.gov/pubmed/25620733 [ ['slom_cah', 'slomt_cah'], 0.8 ], [ ['offh_cah', 'offht_cah'], -15.4 ], [ ['sloh_cah', 'sloht_cah'], 1.05 ] ], [ [ ['offm_cah', 'offmt_cah'], [-24.2, +6.1] ], #http://www.ncbi.nlm.nih.gov/pubmed/23913004 [ ['slom_cah', 'slomt_cah'], [0.7, 1.24] ], [ ['offh_cah', 'offht_cah'], -14.5 ], [ ['sloh_cah', 'sloht_cah'], [0.72, 1.28] ], [ 'taummax_cah', 3.52 ] ], [ [ ['offm_cah', 'offmt_cah'], -17.8 ], #http://www.ncbi.nlm.nih.gov/pubmed/22760075 [ ['slom_cah', 'slomt_cah'], 0.81 ], [ 'taummax_cah', [0.77, 1.31] ] ] ]) #CACNA1I: MT.append([ [ [ ['offm_car'], 1.3 ], #http://www.ncbi.nlm.nih.gov/pubmed/15254077 [ ['offh_car'], 1.6 ], [ 'taummax_car', [0.87, 1.45] ], [ 'tauhmax_car', 0.8 ] ], [ [ 'offm_car', -4.3 ], #http://www.ncbi.nlm.nih.gov/pubmed/12080115 [ 'slom_car', 1.14 ], [ 'offh_car', -4.4 ], [ 'sloh_car', [0.89, 1.04] ], [ 'taummax_car', 0.53 ], [ 'tauhmax_car', 0.46 ] ] ]) #CACNA1S: MT.append([ [ [ 'taummax_cah', 0.67 ] ], #http://www.ncbi.nlm.nih.gov/pubmed/20861472 [ [ ['offm_cah', 'offmt_cah'], -30.02 ], #http://www.ncbi.nlm.nih.gov/pubmed/19134469 [ ['slom_cah', 'slomt_cah'], 0.62 ], [ 'taummax_cah', 0.49] ], [ [ ['offm_cah', 'offmt_cah'], -4.4 ], #http://www.ncbi.nlm.nih.gov/pubmed/24240197 [ ['slom_cah', 'slomt_cah'], 0.95 ], [ ['offh_cah', 'offht_cah'], 20.6 ], [ ['sloh_cah', 'sloht_cah'], 0.97] ] ]) #ATP2A: MT.append([ [ [ 'gamma_cad', 0.6 ] ] ]) #http://www.ncbi.nlm.nih.gov/pubmed/10970890 #ATP2B: MT.append([ [ [ 'taur_cad', 1.97 ] ], #http://www.ncbi.nlm.nih.gov/pubmed/22789621 [ [ 'taur_cad', 1.5 ], #http://www.ncbi.nlm.nih.gov/pubmed/21232211 [ 'cainf_cad' , 1.4 ] ], [ [ 'taur_cad', 4.45 ] ], #http://www.ncbi.nlm.nih.gov/pubmed/17234811 [ [ 'cainf_cad', 1.1 ] ] ]) #http://www.ncbi.nlm.nih.gov/pubmed/22047666 #NRGN: MT.append([ [ [ 'gamma_cad', 0.4 ] ] ]) #http://www.ncbi.nlm.nih.gov/pubmed/15564582 #SCN1A: MT.append([ [ [ ['offm_na', 'offmt_na'], -0.3 ], #http://www.ncbi.nlm.nih.gov/pubmed/18632931 [ ['offh_na', 'offht_na'], 5 ], [ ['slom_na', 'slomt_na'], 1.15 ], [ ['sloh_na', 'sloht_na'], 1.23 ] ], [ [ ['offm_na', 'offmt_na'], 2.8 ], #http://www.ncbi.nlm.nih.gov/pubmed/18632931 [ ['offh_na', 'offht_na'], 9.6 ], [ ['slom_na', 'slomt_na'], 0.984 ], [ ['sloh_na', 'sloht_na'], 1.042 ] ], [ [ ['offm_na', 'offmt_na'], -4.0 ], #http://www.ncbi.nlm.nih.gov/pubmed/21864321 [ ['offh_na', 'offht_na'], -5.8 ], [ ['slom_na', 'slomt_na'], 0.92 ], [ ['sloh_na', 'sloht_na'], 1.13 ], [ ['i1_na', 'i2_na'], 1.47 ] ], [ [ ['offm_na', 'offmt_na'], -8.1 ], #http://www.ncbi.nlm.nih.gov/pubmed/21864321 [ ['offh_na', 'offht_na'], 2.2 ], [ ['slom_na', 'slomt_na'], 0.97 ], [ ['sloh_na', 'sloht_na'], 0.97 ], [ ['i1_na', 'i2_na'], 1.59 ] ], [ [ ['offm_na', 'offmt_na'], 6.0 ], #http://www.ncbi.nlm.nih.gov/pubmed/23398611 [ ['slom_na', 'slomt_na'], 1.16 ], [ ['i1_na', 'i2_na'], 1.29 ] ], [ [ ['offm_na', 'offmt_na'], 10.0 ], #http://www.ncbi.nlm.nih.gov/pubmed/16326807 [ ['offh_na', 'offht_na'], -0.6 ], [ ['slom_na', 'slomt_na'], 1.15 ], [ ['sloh_na', 'sloht_na'], 1.14 ] ] ]) #SCN9A: (Probably no way to include the effects in this model..!) MT.append([ [ [ ['offm_na', 'offmt_na'], 0 ] ], #http://www.ncbi.nlm.nih.gov/pubmed/22136189 [ [ ['offm_na', 'offmt_na'], 0 ] ], #http://www.ncbi.nlm.nih.gov/pubmed/18945915 [ [ ['offm_na', 'offmt_na'], 0 ] ], #http://www.ncbi.nlm.nih.gov/pubmed/16392115 [ [ ['offm_na', 'offmt_na'], 0 ] ] ]) #http://www.ncbi.nlm.nih.gov/pubmed/15958509 #KCNS3: MT.append([ [ [ ['a0_kslow', 'a1_kslow', 'a2_kslow'], 2.0 ], #http://www.ncbi.nlm.nih.gov/pubmed/10484328 [ ['b0_kslow', 'b11_kslow', 'b2_kslow', 'bb0_kslow', 'bb1_kslow', 'bb2_kslow'], 2.5 ], [ 'sloh_kslow', 0.5 ] ] ]) #KCNN3: MT.append([ [ [ 'offc_sk', 0.86 ], #http://www.ncbi.nlm.nih.gov/pubmed/14978258 [ 'sloc_sk', 1.24 ] ], [ [ 'sloc_sk', 0.84 ] ] ]) #http://www.ncbi.nlm.nih.gov/pubmed/17167222 #HCN1: MT.append([ [ [ ['off_iH', 'offt1_iH', 'offt2_iH'], -26.5 ], #http://www.ncbi.nlm.nih.gov/pubmed/17185333 [ ['slo_iH', 'slot1_iH', 'slot2_iH'], 0.64 ] ], [ [ ['off_iH', 'offt1_iH', 'offt2_iH'], [-25.9, 17.7] ], #http://www.ncbi.nlm.nih.gov/pubmed/12668666 [ ['slo_iH', 'slot1_iH', 'slot2_iH'], 0.6 ] ], [ [ ['off_iH', 'offt1_iH', 'offt2_iH'], 3.9 ], #http://www.ncbi.nlm.nih.gov/pubmed/26578877 [ ['t0_iH', 't1_iH'], 0.88 ] ] ]) #KCNB1: MT.append([ [ [ ['offma_kslow', 'offmb_kslow'], 5 ], #http://www.ncbi.nlm.nih.gov/pubmed/21455829 (T203K) [ 'offh_kslow', 3 ], [ ['sloma_kslow', 'slomb_kslow'], 1.11 ], [ 'sloh_kslow', 0.86 ], [ ['a0_kslow', 'a1_kslow', 'a2_kslow'], 0.5 ], [ ['b0_kslow', 'b11_kslow', 'b2_kslow', 'bb0_kslow', 'bb1_kslow', 'bb2_kslow'], 0.53 ] ], [ [ ['offma_kslow', 'offmb_kslow'], 1 ], #http://www.ncbi.nlm.nih.gov/pubmed/21455829 (T203D) [ 'offh_kslow', -6 ], [ ['sloma_kslow', 'slomb_kslow'], 1.22 ], [ 'sloh_kslow', 1.0 ], [ ['a0_kslow', 'a1_kslow', 'a2_kslow'], 0.89 ], [ ['b0_kslow', 'b11_kslow', 'b2_kslow', 'bb0_kslow', 'bb1_kslow', 'bb2_kslow'], 1.13 ] ], [ [ ['offma_kslow', 'offmb_kslow'], 6 ], #http://www.ncbi.nlm.nih.gov/pubmed/21455829 (S347K) [ 'offh_kslow', -8 ], [ ['sloma_kslow', 'slomb_kslow'], 1.33 ], [ 'sloh_kslow', 1.0 ], [ ['a0_kslow', 'a1_kslow', 'a2_kslow'], 0.5 ], [ ['b0_kslow', 'b11_kslow', 'b2_kslow', 'bb0_kslow', 'bb1_kslow', 'bb2_kslow'], 0.87 ] ], [ [ ['offma_kslow', 'offmb_kslow'], -28 ], #http://www.ncbi.nlm.nih.gov/pubmed/21455829 (S347D) [ 'offh_kslow', -27 ], [ ['sloma_kslow', 'slomb_kslow'], 1.11 ], [ 'sloh_kslow', 0.71 ], [ ['a0_kslow', 'a1_kslow', 'a2_kslow'], 1.13 ], [ ['b0_kslow', 'b11_kslow', 'b2_kslow', 'bb0_kslow', 'bb1_kslow', 'bb2_kslow'], 2.27 ] ], [ [ ['offma_kslow', 'offmb_kslow'], 14 ], #http://www.ncbi.nlm.nih.gov/pubmed/21455829 (T203W) [ 'offh_kslow', -21 ], [ ['sloma_kslow', 'slomb_kslow'], 2.0 ], [ 'sloh_kslow', 1.0 ], [ ['a0_kslow', 'a1_kslow', 'a2_kslow'], 0.39 ], [ ['b0_kslow', 'b11_kslow', 'b2_kslow', 'bb0_kslow', 'bb1_kslow', 'bb2_kslow'], 1.2 ] ], [ [ ['offma_kslow', 'offmb_kslow'], -13 ], #http://www.ncbi.nlm.nih.gov/pubmed/21455829 (S347W) [ 'offh_kslow', -13 ], [ ['sloma_kslow', 'slomb_kslow'], 1.33 ], [ 'sloh_kslow', 0.71 ], [ ['a0_kslow', 'a1_kslow', 'a2_kslow'], 0.95 ], [ ['b0_kslow', 'b11_kslow', 'b2_kslow', 'bb0_kslow', 'bb1_kslow', 'bb2_kslow'], 5.13 ] ] ]) #CACNB2 reprise: MT.append([ [ [ ['offm_cah', 'offmt_cah'], 3.00 ], #http://www.ncbi.nlm.nih.gov/pubmed/19723630 (N1 vs N4) [ ['offh_cah', 'offht_cah'], 3.48 ], [ 'taummax_cah', 1.01 ], #(tau_h_slow considered) [ 'tauhmax_cah', 0.89 ] ], [ [ ['offm_cah', 'offmt_cah'], -1.11 ], #http://www.ncbi.nlm.nih.gov/pubmed/19723630 (N3 vs N4) [ ['offh_cah', 'offht_cah'], 5.14 ], [ 'taummax_cah', 0.6 ], #(tau_h_slow considered) [ 'tauhmax_cah', 1.48 ] ], [ [ ['offm_cah', 'offmt_cah'], -1.88 ], #http://www.ncbi.nlm.nih.gov/pubmed/19723630 (N5 vs N4) [ ['offh_cah', 'offht_cah'], 2.69 ], [ 'taummax_cah', 0.6 ], #(tau_h_slow considered) [ 'tauhmax_cah', 1.35 ] ] ]) #KCNMA1: MT.append([ [ [ 'offm_bk', [-13.8, 57.0] ], #http://www.ncbi.nlm.nih.gov/pubmed/16100257 (E912A, D916A, N918A, Q920A, D923A) [ ['ctm_bk', 'ctmmax_bk'], [0.51, 2.75] ] ], [ [ 'offm_bk', 49.2 ] ], #http://www.ncbi.nlm.nih.gov/pubmed/24067659 (Slo1C-KvT, Slo1C-Kv-minT) [ [ 'offm_bk', 16 ], #http://www.ncbi.nlm.nih.gov/pubmed/11880513 (hslo) [ ['ctm_bk', 'ctmmax_bk'], 5.91 ] ], [ [ 'offm_bk', [-5, 15] ], #http://www.ncbi.nlm.nih.gov/pubmed/18719396 (e9alt, e9+e9alt) (voltage midpoint for [Ca]=5nM, tau for [Ca]=0.1uM) [ ['ctm_bk', 'ctmmax_bk'], 0.13 ] ], [ [ 'offm_bk', -58 ] ] ]) #http://www.ncbi.nlm.nih.gov/pubmed/11880513 (e20,e21,e22 vs ZERO) MTgenes = ['CACNB2', 'CACNA1D', 'CACNA1I', 'CACNA1S', 'ATP2A2', 'ATP2B2', 'NRGN', 'SCN1A', 'SCN9A', 'KCNS3', 'HCN1', 'KCNB1', 'CACNB2', 'KCNMA1'] print "MT loaded successfully:" print MT return MT def getparamwiseMT(): MT = [ [ ['offm_cah', 'offmt_cah'], [-37.3, 12.9] ], [ ['offh_cah', 'offht_cah'], [-30.0, 20.6] ], [ ['slom_cah', 'slomt_cah'], [0.46, 1.56] ], [ ['sloh_cah', 'sloht_cah'], [0.66, 1.38] ], [ ['taummax_cah'], [0.49, 1.7] ], [ ['tauhmax_cah'], [0.5, 3.52] ], [ ['offm_car'], [-4.3, 1.3] ], [ ['offh_car'], [-4.4, 1.6] ], [ ['slom_car'], [1.14, 1.14] ], [ ['sloh_car'], [0.89, 1.04] ], [ ['taummax_car'], [0.53, 1.45] ], [ ['tauhmax_car'], [0.46, 0.8] ], [ ['gamma_cad'], [0.4, 0.6] ], [ ['taur_cad'], [1.5, 4.45] ], [ ['cainf_cad'], [1.1, 1.4] ], [ ['offm_na', 'offmt_na'], [-9.1, 10.0] ], [ ['offh_na', 'offht_na'], [-5.8, 17.0] ], [ ['slom_na', 'slomt_na'], [0.92, 1.16] ], [ ['sloh_na', 'sloht_na'], [0.69, 1.23] ], [ ['i1_na', 'i2_na'], [1.29, 1.59] ], [ ['offma_kslow', 'offmb_kslow'], [-28.0, 14.0] ], [ ['offh_kslow'],[-27.0, 3.0] ], [ ['sloma_kslow', 'slomb_kslow'], [1.11, 2.0] ], [ ['sloh_kslow'], [0.5, 1.0] ], [ ['a0_kslow', 'a1_kslow', 'a2_kslow'], [0.39, 2.0] ], [ ['b0_kslow', 'b11_kslow', 'b2_kslow', 'bb0_kslow', 'bb1_kslow', 'bb2_kslow'], [0.53, 2.5] ], [ ['offc_sk'], [0.86, 0.86] ], [ ['sloc_sk'], [0.84, 1.24] ], [ ['off_iH', 'offt1_iH', 'offt2_iH'], [-26.5, 17.7] ], [ ['slo_iH', 'slot1_iH', 'slot2_iH'], [0.6, 0.64] ], [ ['t0_iH', 't1_iH'], [0.88, 0.88] ], [ ['offm_bk'], [-58.0, 57.0] ], [ ['ctm_bk', 'ctmmax_bk'], [0.13, 5.91] ] ] print "MT loaded successfully:" print MT return MT def getdefvals(): defVals = {'gamma_cad': 1.00, 'taur_cad': 80.0, 'depth_cad': 0.1, 'cainf_cad': 1e-4, 'offm_cah': -14.17, 'offmt_cah': -26.31, 'offh_cah': -22.63, 'offht_cah': 19.73, 'slom_cah': 9.76, 'slomt_cah': 31.25, 'sloh_cah': 6.6, 'sloht_cah': 1/0.047, 'taummax_cah': 0.97, 'tauhmax_cah': 70, 'offm_car': -23.0, 'offmt_car': -23.0, 'offh_car': -79.0, 'offht_car': -79.0, 'slom_car': 7.4, 'slomt_car': 31.25, 'sloh_car': 7.8, 'sloht_car': 1/0.047, 'taummax_car': 5.5, 'tauhmax_car': 771.0, 'eh_iH': -33.0, 'off_iH': -91.0, 'slo_iH': 6.0, 'offt1_iH': -0.0, 'offt2_iH': -0.0, 't0_iH': 1.0/0.0003933, 't1_iH': 1.0/0.0877, 'slot1_iH': 1.0/0.0249, 'slot2_iH': 1.0/0.062, 'offh_kslow': -58, 'sloh_kslow': 11.0, 'a0_kslow': 1.0/0.0052, 'a1_kslow': 1.0/0.01938, 'a2_kslow': 1.0/0.0053, 'offma_kslow': 11.1, 'sloma_kslow': 13.1, 'offmb_kslow': -1.27, 'slomb_kslow': 71, 'b0_kslow': 360.0, 'b11_kslow': 1010.0, 'b2_kslow': 23.7, 'offht1_kslow': -54.0, 'offht2_kslow': -75.0, 'sloht2_kslow': 48.0, 'bb0_kslow': 2350.0, 'bb1_kslow': 1380.0, 'bb2_kslow': -210.0, 'offht3_kslow': 0.0, 'offht4_kslow': 0.0, 'sloht3_kslow': 1.0/0.01118, 'sloht4_kslow': 1.0/0.0306, 'offn_iA': -47.0, 'slon_iA': 29.0, 'offl_iA': -66.0, 'slol_iA': 10, 'offmt_iA': -71.0, 'slomt_iA': 59.0, 'taummin_iA': 0.34, 'taumdiff_iA': 0.92, 'offht_iA': -73.0, 'sloht_iA': 23.0, 'tauhmin_iA': 8.0, 'tauhdiff_iA': 49.0, 'offm_na': -38.0, 'slom_na': 10.0, 'offh_na': -66.0, 'sloh_na': 6.0, 'a1_na': 0.058, 'a2_na': 0.114, 'offmt_na': -36.0, 'slomt_na': 28.0, 'i1_na': 0.28, 'i2_na': 16.7, 'offht_na': -60.0, 'sloht_na': 25.0, 'b0inv_sk': 1.0/0.06, 'offc_sk': (0.06/1.3e4)**0.25, 'sloc_sk': 4.0, 'zhalf_bk': 0.01, 'offm_bk': -28.9, 'slom_bk': 6.2, 'ctm_bk': 0.000505, 'ctmmax_bk': 1.0, 'offmt1_bk': -86.4, 'slomt1_bk': 10.1, 'offmt2_bk': 33.3, 'slomt2_bk': 10.0, 'ctauz_bk': 1.0, 'ch_bk': 0.085, 'offh_bk': -32.0, 'sloh_bk': 5.8, 'cth_bk': 0.0019, 'cthmax_bk': 1.0, 'offht1_bk': -48.5, 'sloht1_bk': 5.2, 'offht2_bk': 54.2, 'sloht2_bk': 12.9} print "defVals loaded successfully:" print defVals return defVals def getsuffixes(): return ['cad','cah','car','iH','kslow','iA','na','sk','bk'] def getsuffixexceptions(): return [[],[],[],[['eh_iH','eh']],[],[],[],[],[]] def getgenenames(): return ['CACNA1C', 'CACNB2', 'CACNA1D', 'CACNA1I', 'CACNA1S', 'ATP2A2', 'ATP2B2', 'NRGN', 'SCN1A', 'SCN9A', 'KCNS3', 'KCNN3', 'HCN1', 'KCNB1', 'CACNB2', 'KCNMA1'] #return ['CACNB2b', 'CACNA1D', 'CACNA1I', 'CACNA1S', 'ATP2A2', 'ATP2B2', 'NRGN', 'SCN1A', 'SCN9A', 'KCNS3', 'HCN1'] def getArticles(): # List of genes # List of mutations Articles = [] #CACNA1C: Articles.append([ 'http://www.ncbi.nlm.nih.gov/pubmed/19265197', 'http://www.ncbi.nlm.nih.gov/pubmed/19265197' ]) #CACNB2: Articles.append([ 'http://www.ncbi.nlm.nih.gov/pubmed/19358333', 'http://www.ncbi.nlm.nih.gov/pubmed/7723731', 'http://www.ncbi.nlm.nih.gov/pubmed/19723630']) #CACNA1D: Articles.append([ 'http://www.ncbi.nlm.nih.gov/pubmed/21998309 and http://www.ncbi.nlm.nih.gov/pubmed/21998310 (42A)', 'http://www.ncbi.nlm.nih.gov/pubmed/21998309 and http://www.ncbi.nlm.nih.gov/pubmed/21998310 (43S)', 'http://www.ncbi.nlm.nih.gov/pubmed/20951705 and http://www.ncbi.nlm.nih.gov/pubmed/21054386 (CaV1.3 KO)']) #CACNA1I: Articles.append([ 'http://www.ncbi.nlm.nih.gov/pubmed/15254077']) #CACNA1S: Articles.append([ 'http://www.ncbi.nlm.nih.gov/pubmed/20861472', 'http://www.ncbi.nlm.nih.gov/pubmed/19134469']) #ATP2A: Articles.append([ 'http://www.ncbi.nlm.nih.gov/pubmed/10970890']) #ATP2B: Articles.append([ 'http://www.ncbi.nlm.nih.gov/pubmed/22789621', 'http://www.ncbi.nlm.nih.gov/pubmed/21232211', 'http://www.ncbi.nlm.nih.gov/pubmed/17234811']) #NRGN: Articles.append([ 'http://www.ncbi.nlm.nih.gov/pubmed/15564582']) #SCN1A: Articles.append([ 'http://www.ncbi.nlm.nih.gov/pubmed/18632931', 'http://www.ncbi.nlm.nih.gov/pubmed/18632931']) #SCN9A: (Probably no way to include the effects in this model..!) Articles.append([ 'http://www.ncbi.nlm.nih.gov/pubmed/22136189', 'http://www.ncbi.nlm.nih.gov/pubmed/18945915', 'http://www.ncbi.nlm.nih.gov/pubmed/16392115', 'http://www.ncbi.nlm.nih.gov/pubmed/15958509']) #KCNS3: Articles.append([ 'http://www.ncbi.nlm.nih.gov/pubmed/10484328']) #KCNN3: Articles.append([ 'http://www.ncbi.nlm.nih.gov/pubmed/14978258']) #HCN1: Articles.append([ 'http://www.ncbi.nlm.nih.gov/pubmed/17185333']) #KCNB1: Articles.append([ 'http://www.ncbi.nlm.nih.gov/pubmed/21455829 (T203K)', 'http://www.ncbi.nlm.nih.gov/pubmed/21455829 (T203D)', 'http://www.ncbi.nlm.nih.gov/pubmed/21455829 (S347K)', 'http://www.ncbi.nlm.nih.gov/pubmed/21455829 (S347D)', 'http://www.ncbi.nlm.nih.gov/pubmed/21455829 (T203W)', 'http://www.ncbi.nlm.nih.gov/pubmed/21455829 (S347W)']) #CACNB2 reprise: Articles.append([ 'http://www.ncbi.nlm.nih.gov/pubmed/19723630 (N1 vs N4)', 'http://www.ncbi.nlm.nih.gov/pubmed/19723630 (N3 vs N4)', 'http://www.ncbi.nlm.nih.gov/pubmed/19723630 (N5 vs N4)']) #KCNMA1: Articles.append([ 'http://www.ncbi.nlm.nih.gov/pubmed/16100257 (E912A, D916A, N918A, Q920A, D923A)', 'http://www.ncbi.nlm.nih.gov/pubmed/24067659 (Slo1C-KvT, Slo1C-Kv-minT)', 'http://www.ncbi.nlm.nih.gov/pubmed/11880513 (hslo)', 'http://www.ncbi.nlm.nih.gov/pubmed/2921853 (e9alt, e9+e9alt)', 'http://www.ncbi.nlm.nih.gov/pubmed/11880513 (e20,e21,e22 vs ZERO)']) return Articles