function MT = getMT_kharche() % List of genes % List of mutations % List of groups of variables % Pair (variable list + range) % List of variables MT = []; %CACNA1C: MT = [MT, { { { { 'offm_CaL12', -25.9 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/19265197 { 'offh_CaL12', -27.0 } }, ... { { 'offm_CaL12', -37.3 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/19265197 { 'offh_CaL12', -30.0 } },... { { 'offm_CaL12', [-31.4, +7.0] }, ... %http://www.ncbi.nlm.nih.gov/pubmed/21685391 { 'slom_CaL12', [0.85, 1.45] }, ... { 'offh_CaL12', [-28.5, +16.3] }, ... { 'sloh_CaL12', [0.72, 1.38] } }, ... { { 'offm_CaL12', [-38.5, +12.9] }, ... %http://www.ncbi.nlm.nih.gov/pubmed/16157588 { 'slom_CaL12', [0.46, 1.56] } },... { { 'offm_CaL12', [-27.8, +8.7] }, ... %http://www.ncbi.nlm.nih.gov/pubmed/18836301 { 'slom_CaL12', [0.89, 1.14] },... { 'offh_CaL12', [-19.1, +4.7] } }, ... { { 'offm_CaL12', [-11.2, +1.0] }, ... %http://www.ncbi.nlm.nih.gov/pubmed/15299022 { 'offh_CaL12', -3.1 },... { 'sloh_CaL12', 1.24 } } } }]; %CACNB2: MT = [MT, { { { { {'offh_CaL12', 'offh_CaL13'}, -5.2 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/19358333 { {'sloh_CaL12', 'sloh_CaL13'}, 0.69 } }, ... { { 'tauh_CaL', 1.7} }, ... %http://www.ncbi.nlm.nih.gov/pubmed/7723731 { { {'offm_CaL12', 'offm_CaL13'}, [-4.9, 4.9] }, ... %http://www.ncbi.nlm.nih.gov/pubmed/19723630 { {'offh_CaL12', 'offh_CaL13'}, [-5.1, 5.1] }, ... { 'taum_CaL', [0.6, 1.68] }, ... { 'tauh_CaL', [0.6, 1.66] } },... { { 'tauh_CaL', 1.26} } } }]; %http://www.ncbi.nlm.nih.gov/pubmed/20025708 %CACNA1D: MT = [MT, { { { { 'offm_CaL13', -10.9 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/21998309 and { 'slom_CaL13', 0.73 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/21998310 { 'offh_CaL13', [-3.0, 3.5] }, ... %(42A) { 'sloh_CaL13', 0.81 }, ... { 'tauh_CaL', 1.25 } }, ... { { 'offm_CaL13', [-10.6, 3.4] }, ... %http://www.ncbi.nlm.nih.gov/pubmed/21998309 and { 'slom_CaL13', [0.8, 1.12] }, ... %http://www.ncbi.nlm.nih.gov/pubmed/21998310 { 'offh_CaL13', [-5.3, 1.2] }, ... %(43S) { 'sloh_CaL13', 0.66 }, ... { 'tauh_CaL', 0.72 } }, ... { { 'offm_CaL13', 6.6 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/20951705 and { 'slom_CaL13', [0.75, 1.19] }, ... %http://www.ncbi.nlm.nih.gov/pubmed/21054386 { 'tauh_CaL', [0.5, 1.12] } },... %(CaV1.3 KO) { { 'offm_CaL13', -9.8 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/25620733 { 'slom_CaL13', 0.8 }, ... { 'offh_CaL13', -15.4 }, ... { 'sloh_CaL13', 1.05 } },... { { 'offm_CaL13', [-24.2, +6.1] }, ... %http://www.ncbi.nlm.nih.gov/pubmed/23913004 { 'slom_CaL13', [0.7, 1.24] }, ... { 'offh_CaL13', -14.5 }, ... { 'sloh_CaL13', [0.72, 1.28] }, ... { 'tauh_CaL', 3.52 } },... { { 'offm_CaL13', -17.8 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/22760075 { 'slom_CaL13', 0.81 }, ... { 'tauh_CaL', [0.77, 1.31] } } } }]; %CACNA1I: MT = [MT, { { { { 'offm_CaT', 1.3 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/15254077 { 'offh_CaT', 1.6 }, ... { 'taum_CaT', [0.87, 1.45] }, ... { 'tauh_CaT', 0.8 } },... { { 'offm_CaT', -4.3 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/12080115 { 'slom_CaT', 1.14 }, ... { 'offh_CaT', -4.4 }, ... { 'sloh_CaT', [0.89, 1.04] }, ... { 'taum_CaT', 0.53 }, ... { 'tauh_CaT', 0.46 } } } }]; %CACNA1S: MT = [MT, { { { { 'taum_CaL', 0.67 } }, ... %http://www.ncbi.nlm.nih.gov/pubmed/20861472 { { {'offm_CaL12', 'offm_CaL13'}, -30.02 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/19134469 { {'slom_CaL12', 'slom_CaL13'}, 0.62 }, ... { 'taum_CaL', 0.49} } } }]; %ATP2A: MT = [MT, { { { { 'Pup_SERCA', 0.66 } },... %http://www.ncbi.nlm.nih.gov/pubmed/9891028 { { 'Pup_SERCA', [0.22, 2.31] } },... %http://www.ncbi.nlm.nih.gov/12975374 { { 'Pup_SERCA', 0.2 } } } }]; %http://www.ncbi.nlm.nih.gov/12670936 % %ATP2B: % MT.append([ [ [ 'decay_CaDynamics_E2', 1.97 ] ], %http://www.ncbi.nlm.nih.gov/pubmed/22789621 (N/A) % [ [ 'decay_CaDynamics_E2', 1.5 ], %http://www.ncbi.nlm.nih.gov/pubmed/21232211 (N/A) % [ 'minCai_CaDynamics_E2' , 1.4 ] ], % [ [ 'decay_CaDynamics_E2', 4.45 ] ] ]) %http://www.ncbi.nlm.nih.gov/pubmed/17234811 (N/A) %SCN1A: MT = [MT, { { { { 'offm_NaTTXS', -0.3 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/18632931 { 'offh_NaTTXS', 5 }, ... { 'slom_NaTTXS', 1.15 }, ... { 'sloh_NaTTXS', 1.23 } }, ... { { 'offm_NaTTXS', 2.8 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/17397047 { 'offh_NaTTXS', 9.6 }, ... { 'slom_NaTTXS', 0.984 }, ... { 'sloh_NaTTXS', 1.042 } }, ... { { 'offm_NaTTXS', -4.0 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/21864321 { 'offh_NaTTXS', -5.8 }, ... { 'slom_NaTTXS', 0.92 }, ... { 'sloh_NaTTXS', 1.13 }, ... { 'tauh_NaTTXS', 1.47 } }, ... { { 'offm_NaTTXS', -8.1 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/21864321 { 'offh_NaTTXS', 2.2 }, ... { 'slom_NaTTXS', 0.97 }, ... { 'sloh_NaTTXS', 0.97 }, ... { 'tauh_NaTTXS', 1.59 } }, ... { { 'offm_NaTTXS', 6.0 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/23398611 { 'slom_NaTTXS', 1.16 }, ... { 'tauh_NaTTXS', 1.29 } }, ... { { 'offm_NaTTXS', 10.0 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/16326807 { 'offh_NaTTXS', -0.6 }, ... { 'slom_NaTTXS', 1.15 }, ... { 'sloh_NaTTXS', 1.14 } } } }]; %%SCN9A: % MT = [MT, { { { { {'offh_NaTTXS'}, 0 } }, ... %http://www.ncbi.nlm.nih.gov/pubmed/22136189 (N/A) % { { {'offh_NaTTXS'}, 0 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/18945915 (N/A) % { 'sloh_NaTTXS', 1 }, ... % { 'offm_NaTTXS', 0 }, ... % { 'offh_NaTTXS', 0 }, ... % { 'sloh_NaTTXS', 1 } }, ... % { { 'offm_NaTTXS', 0 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/16392115 (N/A) % { 'offh_NaTTXS', 0 } }, ... % { { 'offm_NaTTXS', 0 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/15958509 (N/A) % { 'offh_NaTTXS', 0 } } } }]; % %KCNS3: % MT = [MT, { { { { {'taum_Kr'}, 1 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/10484328 (N/A) % { {'tauh1_Kr', 'tauh2_Kr'}, 1 }, ... % { 'sloh_Kr', 1 } } } }]; % %KCNN3: % MT = [MT, { { { { 'offc_SK_E2', 0.86 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/14978258 (N/A) % { 'sloc_SK_E2', 1.24 } } } }]; %HCN1: MT = [MT, { { { { 'offh_f', -26.5 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/17185333 { 'sloh_f', 0.64 } }, ... { { 'offh_f', [-25.9, 17.7] }, ... %http://www.ncbi.nlm.nih.gov/pubmed/12668666 { 'sloh_f', 0.6 } }, ... { { 'offh_f', 3.9 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/26578877 { 'tauh_f', 0.88 } } } }]; %CACNB2 reprise: MT = [MT, { { { { {'offm_CaL12', 'offm_CaL13'}, 3 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/19723630 (N1 vs N4) { {'offh_CaL12', 'offh_CaL13'}, 3.48 }, ... { 'taum_CaL', 1.01 }, ... { 'tauh_CaL', 0.89 } },... { { {'offm_CaL12', 'offm_CaL13'}, -1.11 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/19723630 (N3 vs N4) { {'offh_CaL12', 'offh_CaL13'}, 5.14 }, ... { 'taum_CaL', 0.6 }, ... { 'tauh_CaL', 1.48 } },... { { {'offm_CaL12', 'offm_CaL13'}, -1.88 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/19723630 (N5 vs N4) { {'offh_CaL12', 'offh_CaL13'}, 2.69 }, ... { 'taum_CaL', 0.6 }, ... { 'tauh_CaL', 1.35 } } } }]; % %KCNB1: % MT = [MT, { { { { 'offm_K_Pst', 5 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/21455829 (T203K) (N/A) % { 'offh_K_Pst', 3 }, ... % { 'slom_K_Pst', 1.11 }, ... % { 'sloh_K_Pst', 0.86 }, ... % { {'taummin_K_Pst', 'taumdiff1_K_Pst', 'taumdiff2_K_Pst'}, 0.5 }, ... % { {'tauhmean_K_Pst', 'tauhdiff1_K_Pst', 'tauhdiff2_K_Pst'}, 0.53 } }, ... % { { 'offm_K_Pst', 1 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/21455829 (T203D) (N/A) % { 'offh_K_Pst', -6 }, ... % { 'slom_K_Pst', 1.22 }, ... % { 'sloh_K_Pst', 1.0 }, ... % { {'taummin_K_Pst', 'taumdiff1_K_Pst', 'taumdiff2_K_Pst'}, 0.89 }, ... % { {'tauhmean_K_Pst', 'tauhdiff1_K_Pst', 'tauhdiff2_K_Pst'}, 1.13 } }, ... % { { 'offm_K_Pst', 6 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/21455829 (S347K) (N/A) % { 'offh_K_Pst', -8 }, ... % { 'slom_K_Pst', 1.33 }, ... % { 'sloh_K_Pst', 1.0 }, ... % { {'taummin_K_Pst', 'taumdiff1_K_Pst', 'taumdiff2_K_Pst'}, 0.5 }, ... % { {'tauhmean_K_Pst', 'tauhdiff1_K_Pst', 'tauhdiff2_K_Pst'}, 0.87 } }, ... % { { 'offm_K_Pst', -28 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/21455829 (S347D) (N/A) % { 'offh_K_Pst', -27 }, ... % { 'slom_K_Pst', 1.11 }, ... % { 'sloh_K_Pst', 0.71 }, ... % { {'taummin_K_Pst', 'taumdiff1_K_Pst', 'taumdiff2_K_Pst'}, 1.13 }, ... % { {'tauhmean_K_Pst', 'tauhdiff1_K_Pst', 'tauhdiff2_K_Pst'}, 2.27 } }, ... % { { 'offm_K_Pst', 14 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/21455829 (T203W) (N/A) % { 'offh_K_Pst', -21 }, ... % { 'slom_K_Pst', 2.0 }, ... % { 'sloh_K_Pst', 1.0 }, ... % { {'taummin_K_Pst', 'taumdiff1_K_Pst', 'taumdiff2_K_Pst'}, 0.39 }, ... % { {'tauhmean_K_Pst', 'tauhdiff1_K_Pst', 'tauhdiff2_K_Pst'}, 1.2 } }, ... % { { 'offm_K_Pst', -13 }, ... %http://www.ncbi.nlm.nih.gov/pubmed/21455829 (S347W) (N/A) % { 'offh_K_Pst', -13 }, ... % { 'slom_K_Pst', 1.33 }, ... % { 'sloh_K_Pst', 0.71 }, ... % { {'taummin_K_Pst', 'taumdiff1_K_Pst', 'taumdiff2_K_Pst'}, 0.95 }, ... % { {'tauhmean_K_Pst', 'tauhdiff1_K_Pst', 'tauhdiff2_K_Pst'}, 5.13 } } } }];