This directory contains source code used in Fig. 1 of the publication Michalikova M, Remme MWH, Kempter R (2016): Spikelets in Pyramidal Neurons: Action Potentials Initiated in the Axon Initial Segment that do not Activate the Soma, PLOS Comp Biol This model has been adapted from Hu et al.(2009): "Distinct Contributions of Na(V)1.6 and Na(V)1.2 in Action Potential Initiation and Backpropagation" and simulates a layer V pyramidal neuron stimulated with fluctuating synaptic input that generates somatic APs and spikelets. To run this model, either auto-launch from ModelDB or first compile the .mod files (e.g. with "nrnivmodl"), then run the script "Spikelets_Main.hoc" in GUI ("nrngui Spikelets_Main.hoc"). Press "Init & Run" to start the simulation. After about 12 minutes (on a 2012 MacBook pro) you should see a graph like: The graph shows voltage traces at the soma (black) and at the AIS (red). At the soma, APs and spikelets are generated. Somatic spikelets correspond to APs at the AIS.