TITLE Ih-current UNITS { (mA) = (milliamp) (mV) = (millivolt) (mM) = (milli/liter) } INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)} PARAMETER { dt (ms) v (mV) eh = -47 (mV) :ih-reversal potential by Berger gbar = 0.00015 (mho/cm2) :density on dendrite assuming 150pA current and 150mV driving force (=200pS/um2) } NEURON { SUFFIX ih NONSPECIFIC_CURRENT Ih RANGE Ih,gbar } STATE { h } ASSIGNED { Ih (mA/cm2) } INITIAL { h=alpha(v)/(beta(v)+alpha(v)) } BREAKPOINT { SOLVE state METHOD cnexp Ih = gbar*h*(v-eh) } FUNCTION alpha(v(mV)) { alpha = 0.001*6.43*(v+154.9)/(exp((v+154.9)/11.9)-1) :parameters are estimated by direct fitting of HH model to activation time constants and voltage actication curve recorded at 34C by M. Kole } FUNCTION beta(v(mV)) { beta = 0.001*193*exp(v/33.1) } DERIVATIVE state { : exact when v held constant; integrates over dt step h' = (1-h)*alpha(v) - h*beta(v) }