TITLE Fast mechanism for submembranal Ca++ concentration (cai) : : Takes into account: : : - increase of cai due to calcium currents : - extrusion of calcium with a simple first order equation : : This mechanism is compatible with the calcium pump "cad" and has the : same name and parameters; however the parameters specific to the pump : are dummy here. : : Parameters: : : - depth: depth of the shell just beneath the membran (in um) : - cainf: equilibrium concentration of calcium (2e-4 mM) : - taur: time constant of calcium extrusion (must be fast) : - kt,kd: dummy parameters : : Written by Alain Destexhe, Salk Institute, 1995 : INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)} NEURON { SUFFIX cad USEION ca READ ica, cai WRITE cai RANGE depth,kt,kd,cainf,taur } UNITS { (molar) = (1/liter) : moles do not appear in units (mM) = (millimolar) (um) = (micron) (mA) = (milliamp) (msM) = (ms mM) } CONSTANT { FARADAY = 96489 (coul) : moles do not appear in units : FARADAY = 96.489 (k-coul) : moles do not appear in units } PARAMETER { depth = 1 (um) : depth of shell taur = 5 (ms) : rate of calcium removal cainf = 2.4e-4 (mM) kt = 0 (mM/ms) : dummy kd = 0 (mM) : dummy } STATE { cai (mM) } INITIAL { cai = cainf } ASSIGNED { ica (mA/cm2) drive_channel (mM/ms) } BREAKPOINT { SOLVE state METHOD derivimplicit } DERIVATIVE state { drive_channel = - (10000) * ica / (2 * FARADAY * depth) if (drive_channel <= 0.) { drive_channel = 0. } : cannot pump inward cai' = drive_channel + (cainf-cai)/taur }