//-----------------------------------------------------------------------------------------------------------// // Localization of synaptic inputs and Ca-PIC channels over dendrites at the similar distance from the soma // //-----------------------------------------------------------------------------------------------------------// // global constants v_init=-70 num_row=10000 // global variables objref iCaL[num_row] objref iSyn[num_row] // localization of Ca-PIC channels and synaptic inputs at the similar Dpath proc loc_dend(){local max_dist, err_min, i, init, end, err_dist, x_min, j max_dist=0 err_min=0 init=0 end=0 err_dist=0 x_min=0 j=0 // calculate the longest Dpath from the soma forall { soma distance(0, 0) for(x){ if (max_dist < distance(x)) { max_dist = distance(x) } } err_min=max_dist } // set the specific Dpath i = 600 forall { init = distance(0) end = distance(1) if (init<=i && i err_dist) { err_min = err_dist x_min=x } } if(x_min==0){x_min=0.0001} if(x_min==1){x_min=0.9999} iCaL[j] = new CaL(x_min) iCaL[j].gcalbar=1.37 * area(x_min) * (10^-4)^2 * 10^3 //600um [mS/cm2] iSyn[j] = new StepSyn(x_min) iSyn[j].ip1=0.4 * area(x_min) * (10^-4)^2 * 10^3 //600um [mS/cm2] iSyn[j].ip2=-0.3 * area(x_min) * (10^-4)^2 * 10^3 //600um [mS/cm2] iSyn[j].ip3=0.2 * area(x_min) * (10^-4)^2 * 10^3 //600um [mS/cm2] iSyn[j].ip4=0.3 * area(x_min) * (10^-4)^2 * 10^3 //600um [mS/cm2] iSyn[j].ip5=-0.41 * area(x_min) * (10^-4)^2 * 10^3 //600um [mS/cm2] iSyn[j].i0=0.25 * area(x_min) * (10^-4)^2 * 10^3 //600um [mS/cm2] iSyn[j].s=1 j=j+1 err_min=max_dist } } } loc_dend()