def getMT(doprint=True): # List of genes # List of mutations # List of groups of variables # Pair (variable list + range) # List of variables MT = [] #CACNA1C: MT.append([ [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], -25.9 ], #http://www.ncbi.nlm.nih.gov/pubmed/19265197 [ ['offha_Ca_HVA', 'offhb_Ca_HVA'], -27.0 ] ], [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], -37.3 ], #http://www.ncbi.nlm.nih.gov/pubmed/19265197 [ ['offha_Ca_HVA', 'offhb_Ca_HVA'], -30.0 ] ], [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], [-31.4, +7.0] ], #http://www.ncbi.nlm.nih.gov/pubmed/21685391 [ ['sloma_Ca_HVA', 'slomb_Ca_HVA'], [0.85, 1.45] ], [ ['offha_Ca_HVA', 'offhb_Ca_HVA'], [-28.5, +16.3] ], [ ['sloha_Ca_HVA', 'slohb_Ca_HVA'], [0.72, 1.38] ] ], [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], [-38.5, +12.9] ], #http://www.ncbi.nlm.nih.gov/pubmed/16157588 [ ['sloma_Ca_HVA', 'slomb_Ca_HVA'], [0.46, 1.56] ] ], [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], [-27.8, +8.7] ], #http://www.ncbi.nlm.nih.gov/pubmed/18836301 [ ['sloma_Ca_HVA', 'slomb_Ca_HVA'], [0.89, 1.14] ], [ ['offha_Ca_HVA', 'offhb_Ca_HVA'], [-19.1, +4.7] ] ], [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], [-11.2, +1.0] ], #http://www.ncbi.nlm.nih.gov/pubmed/15299022 [ ['offha_Ca_HVA', 'offhb_Ca_HVA'], -3.1 ], [ ['sloha_Ca_HVA', 'slohb_Ca_HVA'], 1.24 ] ] ]) #CACNB2: MT.append([ [ [ ['offha_Ca_HVA', 'offhb_Ca_HVA'], -5.2 ], #http://www.ncbi.nlm.nih.gov/pubmed/19358333 [ ['sloha_Ca_HVA', 'slohb_Ca_HVA'], 0.69 ] ], [ [ ['tauha_Ca_HVA', 'tauhb_Ca_HVA'], 1.7] ], #http://www.ncbi.nlm.nih.gov/pubmed/7723731 [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], [-4.9, 4.9] ], #http://www.ncbi.nlm.nih.gov/pubmed/19723630 [ ['offha_Ca_HVA', 'offhb_Ca_HVA'], [-5.1, 5.1] ], [ ['tauma_Ca_HVA', 'taumb_Ca_HVA'], [0.6, 1.68] ], [ ['tauha_Ca_HVA', 'tauhb_Ca_HVA'], [0.6, 1.66] ] ], [ [ ['tauha_Ca_HVA', 'tauhb_Ca_HVA'], 1.26] ] ]) #http://www.ncbi.nlm.nih.gov/pubmed/20025708 #CACNA1D: MT.append([ [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], -10.9 ], #http://www.ncbi.nlm.nih.gov/pubmed/21998309 and [ ['sloma_Ca_HVA', 'slomb_Ca_HVA'], 0.73 ], #http://www.ncbi.nlm.nih.gov/pubmed/21998310 [ ['offha_Ca_HVA', 'offhb_Ca_HVA'], [-3.0, 3.5] ], #(42A) [ ['sloha_Ca_HVA', 'slohb_Ca_HVA'], 0.81 ], [ ['tauha_Ca_HVA', 'tauhb_Ca_HVA'], 1.25 ] ], [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], [-10.6, 3.4] ], #http://www.ncbi.nlm.nih.gov/pubmed/21998309 and [ ['sloma_Ca_HVA', 'slomb_Ca_HVA'], [0.8, 1.12] ], #http://www.ncbi.nlm.nih.gov/pubmed/21998310 [ ['offha_Ca_HVA', 'offhb_Ca_HVA'], [-5.3, 1.2] ], #(43S) [ ['sloha_Ca_HVA', 'slohb_Ca_HVA'], 0.66 ], [ ['tauha_Ca_HVA', 'tauhb_Ca_HVA'], 0.72 ] ], [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], 6.6 ], #http://www.ncbi.nlm.nih.gov/pubmed/20951705 and [ ['sloma_Ca_HVA', 'slomb_Ca_HVA'], [0.75, 1.19] ], #http://www.ncbi.nlm.nih.gov/pubmed/21054386 [ ['tauha_Ca_HVA', 'tauhb_Ca_HVA'], [0.5, 1.12] ] ], #(CaV1.3 KO) [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], -9.8 ], #http://www.ncbi.nlm.nih.gov/pubmed/25620733 [ ['sloma_Ca_HVA', 'slomb_Ca_HVA'], 0.8 ], [ ['offha_Ca_HVA', 'offhb_Ca_HVA'], -15.4 ], [ ['sloha_Ca_HVA', 'slohb_Ca_HVA'], 1.05 ] ], [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], [-24.2, +6.1] ], #http://www.ncbi.nlm.nih.gov/pubmed/23913004 [ ['sloma_Ca_HVA', 'slomb_Ca_HVA'], [0.7, 1.24] ], [ ['offha_Ca_HVA', 'offhb_Ca_HVA'], -14.5 ], [ ['sloha_Ca_HVA', 'slohb_Ca_HVA'], [0.72, 1.28] ], [ ['tauha_Ca_HVA', 'tauhb_Ca_HVA'], 3.52 ] ], [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], -17.8 ], #http://www.ncbi.nlm.nih.gov/pubmed/22760075 [ ['sloma_Ca_HVA', 'slomb_Ca_HVA'], 0.81 ], [ ['tauha_Ca_HVA', 'tauhb_Ca_HVA'], [0.77, 1.31] ] ] ]) #CACNA1I: MT.append([ [ [ 'offma_Ca_LVAst', 1.3 ], #http://www.ncbi.nlm.nih.gov/pubmed/15254077 [ 'offha_Ca_LVAst', 1.6 ], [ ['taummin_Ca_LVAst', 'taumdiff_Ca_LVAst'], [0.87, 1.45] ], [ ['tauhmin_Ca_LVAst', 'tauhdiff_Ca_LVAst'], 0.8 ] ], [ [ 'offma_Ca_LVAst', -4.3 ], #http://www.ncbi.nlm.nih.gov/pubmed/12080115 [ 'sloma_Ca_LVAst', 1.14 ], [ 'offha_Ca_LVAst', -4.4 ], [ 'sloha_Ca_LVAst', [0.89, 1.04] ], [ ['taummin_Ca_LVAst', 'taumdiff_Ca_LVAst'], 0.53 ], [ ['tauhmin_Ca_LVAst', 'tauhdiff_Ca_LVAst'], 0.46 ] ] ]) #CACNA1S: MT.append([ [ [ ['tauma_Ca_HVA', 'taumb_Ca_HVA'], 0.67 ] ], #http://www.ncbi.nlm.nih.gov/pubmed/20861472 [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], -30.02 ], #http://www.ncbi.nlm.nih.gov/pubmed/19134469 [ ['sloma_Ca_HVA', 'slomb_Ca_HVA'], 0.62 ], [ ['tauma_Ca_HVA', 'taumb_Ca_HVA'], 0.49] ], [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], -4.4 ], #http://www.ncbi.nlm.nih.gov/pubmed/24240197 [ ['sloma_Ca_HVA', 'slomb_Ca_HVA'], 0.95 ], [ ['offha_Ca_HVA', 'offhb_Ca_HVA'], 20.6 ], [ ['sloha_Ca_HVA', 'slohb_Ca_HVA'], 0.97] ] ]) #ATP2A: MT.append([ [ [ 'gamma_CaDynamics_E2', 0.6 ] ] ]) #http://www.ncbi.nlm.nih.gov/pubmed/10970890 #MT = [MT, { { { { 'Pup_SERCA', 0.66 ] ], #http://www.ncbi.nlm.nih.gov/pubmed/9891028 # [ [ [ 'Pup_SERCA', [0.22, 2.31] ] ], #http://www.ncbi.nlm.nih.gov/pubmed/12975374 # [ [ [ 'Pup_SERCA', 0.2 ] ] ]) #http://www.ncbi.nlm.nih.gov/pubmed/12670936 #ATP2B: MT.append([ [ [ 'decay_CaDynamics_E2', 1.97 ] ], #http://www.ncbi.nlm.nih.gov/pubmed/22789621 [ [ 'decay_CaDynamics_E2', 1.5 ], #http://www.ncbi.nlm.nih.gov/pubmed/21232211 [ 'minCai_CaDynamics_E2' , 1.4 ] ], [ [ 'decay_CaDynamics_E2', 4.45 ] ], #http://www.ncbi.nlm.nih.gov/pubmed/17234811 [ [ 'minCai_CaDynamics_E2', 1.1 ] ] ]) #http://www.ncbi.nlm.nih.gov/pubmed/22047666 #NRGN: MT.append([ [ [ 'gamma_CaDynamics_E2', 0.4 ] ] ]) #http://www.ncbi.nlm.nih.gov/pubmed/15564582 #SCN1A: MT.append([ [ [ 'offm_NaTa_t', -0.3 ], #http://www.ncbi.nlm.nih.gov/pubmed/18632931 [ 'offh_NaTa_t', 5 ], [ 'slom_NaTa_t', 1.15 ], [ 'sloh_NaTa_t', 1.23 ] ], [ [ 'offm_NaTa_t', 2.8 ], #http://www.ncbi.nlm.nih.gov/pubmed/18632931 [ 'offh_NaTa_t', 9.6 ], [ 'slom_NaTa_t', 0.984 ], [ 'sloh_NaTa_t', 1.042 ] ], [ [ 'offm_NaTa_t', -4.0 ], #http://www.ncbi.nlm.nih.gov/pubmed/21864321 [ 'offh_NaTa_t', -5.8 ], [ 'slom_NaTa_t', 0.92 ], [ 'sloh_NaTa_t', 1.13 ], [ ['tauha_NaTa_t', 'tauhb_NaTa_t'], 1.47 ] ], [ [ 'offm_NaTa_t', -8.1 ], #http://www.ncbi.nlm.nih.gov/pubmed/21864321 [ 'offh_NaTa_t', 2.2 ], [ 'slom_NaTa_t', 0.97 ], [ 'sloh_NaTa_t', 0.97 ], [ ['tauha_NaTa_t', 'tauhb_NaTa_t'], 1.59 ] ], [ [ 'offm_NaTa_t', 6.0 ], #http://www.ncbi.nlm.nih.gov/pubmed/23398611 [ 'slom_NaTa_t', 1.16 ], [ ['tauha_NaTa_t', 'tauhb_NaTa_t'], 1.29 ] ], [ [ 'offm_NaTa_t', 10.0 ], #http://www.ncbi.nlm.nih.gov/pubmed/16326807 [ 'offh_NaTa_t', -0.6 ], [ 'slom_NaTa_t', 1.15 ], [ 'sloh_NaTa_t', 1.14 ] ] ]) #SCN9A: MT.append([ [ [ ['offh_Nap_Et2', 'offha_Nap_Et2', 'offhb_Nap_Et2'], 6.8 ] ], #http://www.ncbi.nlm.nih.gov/pubmed/22136189 [ [ ['offh_Nap_Et2', 'offha_Nap_Et2', 'offhb_Nap_Et2'], 3.5 ], #http://www.ncbi.nlm.nih.gov/pubmed/18945915 [ 'sloh_Nap_Et2', 0.55 ], [ 'offm_NaTa_t', -7.1 ], [ 'offh_NaTa_t', 17.0 ], [ 'sloh_NaTa_t', 0.69 ] ], [ [ 'offm_NaTa_t', -9.1 ], #http://www.ncbi.nlm.nih.gov/pubmed/16392115 [ 'offh_NaTa_t', 3.1 ] ], [ [ 'offm_NaTa_t', -7.6 ], #http://www.ncbi.nlm.nih.gov/pubmed/15958509 [ 'offh_NaTa_t', 4.3 ] ] ]) #KCNS3: MT.append([ [ [ ['taummin_K_Pst', 'taumdiff1_K_Pst', 'taumdiff2_K_Pst'], 2.0 ], #http://www.ncbi.nlm.nih.gov/pubmed/10484328 [ ['tauhmean_K_Pst', 'tauhdiff1_K_Pst', 'tauhdiff2_K_Pst'], 2.5 ], [ 'sloh_K_Pst', 0.5 ] ] ]) #KCNN3: MT.append([ [ [ 'offc_SK_E2', 0.86 ], #http://www.ncbi.nlm.nih.gov/pubmed/14978258 [ 'sloc_SK_E2', 1.24 ] ], [ [ 'sloc_SK_E2', 0.84 ] ] ]) #http://www.ncbi.nlm.nih.gov/pubmed/17167222 #HCN1: MT.append([ [ [ ['offma_Ih', 'offmb_Ih'], -26.5 ], #http://www.ncbi.nlm.nih.gov/pubmed/17185333 [ ['sloma_Ih', 'slomb_Ih'], 0.64 ] ], [ [ ['offma_Ih', 'offmb_Ih'], [-25.9, 17.7] ], #http://www.ncbi.nlm.nih.gov/pubmed/12668666 [ ['sloma_Ih', 'slomb_Ih'], 0.6 ] ], [ [ ['offma_Ih', 'offmb_Ih'], 3.9 ], #http://www.ncbi.nlm.nih.gov/pubmed/26578877 [ ['tauma_Ih', 'taumb_Ih'], 0.88 ] ] ]) #KCNB1: MT.append([ [ [ 'offm_K_Pst', 5 ], #http://www.ncbi.nlm.nih.gov/pubmed/21455829 (T203K) [ 'offh_K_Pst', 3 ], [ 'slom_K_Pst', 1.11 ], [ 'sloh_K_Pst', 0.86 ], [ ['taummin_K_Pst', 'taumdiff1_K_Pst', 'taumdiff2_K_Pst'], 0.5 ], [ ['tauhmean_K_Pst', 'tauhdiff1_K_Pst', 'tauhdiff2_K_Pst'], 0.53 ] ], [ [ 'offm_K_Pst', 1 ], #http://www.ncbi.nlm.nih.gov/pubmed/21455829 (T203D) [ 'offh_K_Pst', -6 ], [ 'slom_K_Pst', 1.22 ], [ 'sloh_K_Pst', 1.0 ], [ ['taummin_K_Pst', 'taumdiff1_K_Pst', 'taumdiff2_K_Pst'], 0.89 ], [ ['tauhmean_K_Pst', 'tauhdiff1_K_Pst', 'tauhdiff2_K_Pst'], 1.13 ] ], [ [ 'offm_K_Pst', 6 ], #http://www.ncbi.nlm.nih.gov/pubmed/21455829 (S347K) [ 'offh_K_Pst', -8 ], [ 'slom_K_Pst', 1.33 ], [ 'sloh_K_Pst', 1.0 ], [ ['taummin_K_Pst', 'taumdiff1_K_Pst', 'taumdiff2_K_Pst'], 0.5 ], [ ['tauhmean_K_Pst', 'tauhdiff1_K_Pst', 'tauhdiff2_K_Pst'], 0.87 ] ], [ [ 'offm_K_Pst', -28 ], #http://www.ncbi.nlm.nih.gov/pubmed/21455829 (S347D) [ 'offh_K_Pst', -27 ], [ 'slom_K_Pst', 1.11 ], [ 'sloh_K_Pst', 0.71 ], [ ['taummin_K_Pst', 'taumdiff1_K_Pst', 'taumdiff2_K_Pst'], 1.13 ], [ ['tauhmean_K_Pst', 'tauhdiff1_K_Pst', 'tauhdiff2_K_Pst'], 2.27 ] ], [ [ 'offm_K_Pst', 14 ], #http://www.ncbi.nlm.nih.gov/pubmed/21455829 (T203W) [ 'offh_K_Pst', -21 ], [ 'slom_K_Pst', 2.0 ], [ 'sloh_K_Pst', 1.0 ], [ ['taummin_K_Pst', 'taumdiff1_K_Pst', 'taumdiff2_K_Pst'], 0.39 ], [ ['tauhmean_K_Pst', 'tauhdiff1_K_Pst', 'tauhdiff2_K_Pst'], 1.2 ] ], [ [ 'offm_K_Pst', -13 ], #http://www.ncbi.nlm.nih.gov/pubmed/21455829 (S347W) [ 'offh_K_Pst', -13 ], [ 'slom_K_Pst', 1.33 ], [ 'sloh_K_Pst', 0.71 ], [ ['taummin_K_Pst', 'taumdiff1_K_Pst', 'taumdiff2_K_Pst'], 0.95 ], [ ['tauhmean_K_Pst', 'tauhdiff1_K_Pst', 'tauhdiff2_K_Pst'], 5.13 ] ] ]) #CACNB2 reprise: MT.append([ [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], 3.00 ], #http://www.ncbi.nlm.nih.gov/pubmed/19723630 (N1 vs N4) [ ['offha_Ca_HVA', 'offhb_Ca_HVA'], 3.48 ], [ ['tauma_Ca_HVA', 'taumb_Ca_HVA'], 1.01 ], #(tau_h_slow considered) [ ['tauha_Ca_HVA', 'tauhb_Ca_HVA'], 0.89 ] ], [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], -1.11 ], #http://www.ncbi.nlm.nih.gov/pubmed/19723630 (N3 vs N4) [ ['offha_Ca_HVA', 'offhb_Ca_HVA'], 5.14 ], [ ['tauma_Ca_HVA', 'taumb_Ca_HVA'], 0.6 ], #(tau_h_slow considered) [ ['tauha_Ca_HVA', 'tauhb_Ca_HVA'], 1.48 ] ], [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], -1.88 ], #http://www.ncbi.nlm.nih.gov/pubmed/19723630 (N5 vs N4) [ ['offha_Ca_HVA', 'offhb_Ca_HVA'], 2.69 ], [ ['tauma_Ca_HVA', 'taumb_Ca_HVA'], 0.6 ], #(tau_h_slow considered) [ ['tauha_Ca_HVA', 'tauhb_Ca_HVA'], 1.35 ] ] ]) MTgenes = ['CACNB2', 'CACNA1D', 'CACNA1I', 'CACNA1S', 'ATP2A2', 'ATP2B2', 'NRGN', 'SCN1A', 'SCN9A', 'KCNS3', 'HCN1', 'KCNB1', 'CACNB2'] if doprint: print "MT loaded successfully:" print MT return MT def getparamwiseMT(): MT = [ [ ['offma_Ca_HVA', 'offmb_Ca_HVA'], [-37.3, 12.9] ], [ ['offha_Ca_HVA', 'offhb_Ca_HVA'], [-30.0, 20.6] ], [ ['sloma_Ca_HVA', 'slomb_Ca_HVA'], [0.46, 1.56] ], [ ['sloha_Ca_HVA', 'slohb_Ca_HVA'], [0.66, 1.38] ], [ ['tauma_Ca_HVA', 'taumb_Ca_HVA'], [0.49, 1.7] ], [ ['tauha_Ca_HVA', 'tauhb_Ca_HVA'], [0.5, 3.52] ], [ ['offma_Ca_LVAst'], [-4.3, 1.3] ], [ ['offha_Ca_LVAst'], [-4.4, 1.6] ], [ ['sloma_Ca_LVAst'], [1.14, 1.14] ], [ ['sloha_Ca_LVAst'], [0.89, 1.04] ], [ ['taummin_Ca_LVAst', 'taumdiff_Ca_LVAst'], [0.53, 1.45] ], [ ['tauhmin_Ca_LVAst', 'tauhdiff_Ca_LVAst'], [0.46, 0.8] ], [ ['gamma_CaDynamics_E2'], [0.4, 0.6] ], [ ['decay_CaDynamics_E2'], [1.5, 4.45] ], [ ['minCai_CaDynamics_E2'], [1.1, 1.4] ], [ ['offm_NaTa_t'], [-9.1, 10.0] ], [ ['offh_NaTa_t'], [-5.8, 17.0] ], [ ['slom_NaTa_t'], [0.92, 1.16] ], [ ['sloh_NaTa_t'], [0.69, 1.23] ], [ ['tauha_NaTa_t', 'tauhb_NaTa_t'], [1.29, 1.59] ], [ ['offh_Nap_Et2', 'offha_Nap_Et2', 'offhb_Nap_Et2'], [3.5, 6.8] ], [ ['sloh_Nap_Et2'], [0.55, 0.55] ], [ ['offm_K_Pst'], [-28.0, 14.0] ], [ ['offh_K_Pst'], [-27.0, 3.0] ], [ ['slom_K_Pst'], [1.11, 2.0] ], [ ['sloh_K_Pst'], [0.5, 1.0] ], [ ['taummin_K_Pst', 'taumdiff1_K_Pst', 'taumdiff2_K_Pst'], [0.39, 2.0] ], [ ['tauhmean_K_Pst', 'tauhdiff1_K_Pst', 'tauhdiff2_K_Pst'], [0.53, 2.5] ], [ ['offc_SK_E2'], [0.86, 0.86] ], [ ['sloc_SK_E2'], [0.84, 1.24] ], [ ['offma_Ih', 'offmb_Ih'], [-26.5, 17.7] ], [ ['sloma_Ih', 'slomb_Ih'], [0.6, 0.64] ], [ ['tauma_Ih', 'taumb_Ih'], [0.88, 0.88] ] ] print "paramwiseMT loaded successfully:" print MT return MT def getdefvals(doprint=True): defVals = {'gamma_CaDynamics_E2': [0.000501, 0.000509], #if two values, the first is for somatic and second for apical segments 'decay_CaDynamics_E2': [460.0, 122.0], 'depth_CaDynamics_E2': 0.1, 'minCai_CaDynamics_E2': 1e-4, 'offma_Ca_HVA': -27.0, 'offmb_Ca_HVA': -75.0, 'offha_Ca_HVA': -13.0, 'offhb_Ca_HVA': -15.0, 'sloma_Ca_HVA': 3.8, 'slomb_Ca_HVA': 17.0, 'sloha_Ca_HVA': 50.0, 'slohb_Ca_HVA': 28.0, 'tauma_Ca_HVA': 1.0/0.055, 'taumb_Ca_HVA': 1.0/0.94, 'tauha_Ca_HVA': 1.0/0.000457, 'tauhb_Ca_HVA': 1.0/0.0065, 'offma_Ca_LVAst': -40.0, 'offmt_Ca_LVAst': -35.0, 'offha_Ca_LVAst': -90.0, 'offht_Ca_LVAst': -50.0, 'sloma_Ca_LVAst': 6.0, 'slomt_Ca_LVAst': 5.0, 'sloha_Ca_LVAst': 6.4, 'sloht_Ca_LVAst': 7.0, 'taummin_Ca_LVAst': 5.0, 'taumdiff_Ca_LVAst': 20.0, 'tauhmin_Ca_LVAst': 20.0, 'tauhdiff_Ca_LVAst': 50.0, 'ehcn_Ih': -45.0, 'offma_Ih': -154.9, 'sloma_Ih': 11.9, 'tauma_Ih': 1.0/0.00643, 'offmb_Ih': 0.0, 'slomb_Ih': 33.1, 'taumb_Ih': 1.0/0.193, 'offma_Im': -35.0, 'sloma_Im': 10.0, 'tauma_Im': 1.0/3.3e-3, 'offmb_Im': -35.0, 'slomb_Im': 10.0, 'taumb_Im': 1.0/3.3e-3, 'offm_K_Pst': -11.0, 'slom_K_Pst': 12.0, 'offmt_K_Pst': -10.0, 'slomt_K_Pst': 1.0/0.026, 'taummin_K_Pst': 1.25, 'taumdiff1_K_Pst': 175.03, 'taumdiff2_K_Pst': 13.0, 'offh_K_Pst': -64.0, 'sloh_K_Pst': 11.0, 'offht1_K_Pst': -65.0, 'offht2_K_Pst': -85.0, 'sloht_K_Pst': 48.0, 'tauhmean_K_Pst': 360.0, 'tauhdiff1_K_Pst': 1010.0, 'tauhdiff2_K_Pst': 24.0, 'offm_K_Tst': -10.0, 'slom_K_Tst': 19.0, 'offh_K_Tst': -76.0, 'sloh_K_Tst': 10.0, 'offmt_K_Tst': -81.0, 'slomt_K_Tst': 59.0, 'taummin_K_Tst': 0.34, 'taumdiff_K_Tst': 0.92, 'offht_K_Tst': -83.0, 'sloht_K_Tst': 23.0, 'tauhmin_K_Tst': 8.0, 'tauhdiff_K_Tst': 49.0, 'offm_NaTa_t': -38.0, 'offh_NaTa_t': -66.0, 'slom_NaTa_t': 6.0, 'sloh_NaTa_t': 6.0, 'tauma_NaTa_t': 1.0/0.182, 'taumb_NaTa_t': 1.0/0.124, 'tauha_NaTa_t': 1.0/0.015, 'tauhb_NaTa_t': 1.0/0.015, 'offm_Nap_Et2': -52.6, 'slom_Nap_Et2': 4.6, 'offma_Nap_Et2': -38.0, 'offmb_Nap_Et2': -38.0, 'sloma_Nap_Et2': 6.0, 'slomb_Nap_Et2': 6.0, 'tauma_Nap_Et2': 1.0/0.182, 'taumb_Nap_Et2': 1.0/0.124, 'taummax_Nap_Et2': 6.0, 'offh_Nap_Et2': -48.8, 'sloh_Nap_Et2': 10.0, 'offha_Nap_Et2': -17.0, 'offhb_Nap_Et2': -64.4, 'sloha_Nap_Et2': 4.63, 'slohb_Nap_Et2': 2.63, 'tauha_Nap_Et2': 1.0/2.88e-6, 'tauhb_Nap_Et2': 1.0/6.94e-6, 'tauhmax_Nap_Et2': 1.0, 'zTau_SK_E2': 1.0, 'offc_SK_E2': 0.00043, 'sloc_SK_E2': 4.8, 'offma_SKv3_1': 18.7, 'offmt_SKv3_1': -46.56, 'sloma_SKv3_1': 9.7, 'slomt_SKv3_1': 44.14, 'taummax_SKv3_1': 4.0} if doprint: print "defVals loaded successfully:" print defVals return defVals def getgenenames(): return ['CACNA1C', 'CACNB2', 'CACNA1D', 'CACNA1I', 'CACNA1S', 'ATP2A2', 'ATP2B2', 'NRGN', 'SCN1A', 'SCN9A', 'KCNS3', 'KCNN3', 'HCN1', 'KCNB1', 'CACNB2'] #return ['CACNB2b', 'CACNA1D', 'CACNA1I', 'CACNA1S', 'ATP2A2', 'ATP2B2', 'NRGN', 'SCN1A', 'SCN9A', 'KCNS3', 'HCN1']