/* Created by Language version: 6.2.0 */ /* VECTORIZED */ #define NRN_VECTORIZED 1 #include #include #include #include "scoplib_ansi.h" #undef PI #define nil 0 #include "md1redef.h" #include "section.h" #include "nrniv_mf.h" #include "md2redef.h" #if METHOD3 extern int _method3; #endif #if !NRNGPU #undef exp #define exp hoc_Exp extern double hoc_Exp(double); #endif #define nrn_init _nrn_init__cadyn #define _nrn_initial _nrn_initial__cadyn #define nrn_cur _nrn_cur__cadyn #define _nrn_current _nrn_current__cadyn #define nrn_jacob _nrn_jacob__cadyn #define nrn_state _nrn_state__cadyn #define _net_receive _net_receive__cadyn #define state state__cadyn #define _threadargscomma_ _p, _ppvar, _thread, _nt, #define _threadargsprotocomma_ double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt, #define _threadargs_ _p, _ppvar, _thread, _nt #define _threadargsproto_ double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt /*SUPPRESS 761*/ /*SUPPRESS 762*/ /*SUPPRESS 763*/ /*SUPPRESS 765*/ extern double *getarg(); /* Thread safe. No static _p or _ppvar. */ #define t _nt->_t #define dt _nt->_dt #define ca _p[0] #define cai _p[1] #define ica _p[2] #define drive_channel _p[3] #define Dca _p[4] #define v _p[5] #define _g _p[6] #define _ion_cai *_ppvar[0]._pval #define _ion_ica *_ppvar[1]._pval #define _style_ca *((int*)_ppvar[2]._pvoid) #if MAC #if !defined(v) #define v _mlhv #endif #if !defined(h) #define h _mlhh #endif #endif #if defined(__cplusplus) extern "C" { #endif static int hoc_nrnpointerindex = -1; static Datum* _extcall_thread; static Prop* _extcall_prop; /* external NEURON variables */ /* declaration of user functions */ static int _mechtype; extern void _nrn_cacheloop_reg(int, int); extern void hoc_register_prop_size(int, int, int); extern void hoc_register_limits(int, HocParmLimits*); extern void hoc_register_units(int, HocParmUnits*); extern void nrn_promote(Prop*, int, int); extern Memb_func* memb_func; extern void _nrn_setdata_reg(int, void(*)(Prop*)); static void _setdata(Prop* _prop) { _extcall_prop = _prop; } static void _hoc_setdata() { Prop *_prop, *hoc_getdata_range(int); _prop = hoc_getdata_range(_mechtype); _setdata(_prop); hoc_retpushx(1.); } /* connect user functions to hoc names */ static VoidFunc hoc_intfunc[] = { "setdata_cadyn", _hoc_setdata, 0, 0 }; /* declare global and static user variables */ #define cainf cainf_cadyn double cainf = 5e-05; #define depth depth_cadyn double depth = 0.1; #define taur taur_cadyn double taur = 200; /* some parameters have upper and lower limits */ static HocParmLimits _hoc_parm_limits[] = { 0,0,0 }; static HocParmUnits _hoc_parm_units[] = { "depth_cadyn", "um", "taur_cadyn", "ms", "cainf_cadyn", "mM", "ca_cadyn", "mM", 0,0 }; static double ca0 = 0; static double delta_t = 0.01; /* connect global user variables to hoc */ static DoubScal hoc_scdoub[] = { "depth_cadyn", &depth_cadyn, "taur_cadyn", &taur_cadyn, "cainf_cadyn", &cainf_cadyn, 0,0 }; static DoubVec hoc_vdoub[] = { 0,0,0 }; static double _sav_indep; static void nrn_alloc(Prop*); static void nrn_init(_NrnThread*, _Memb_list*, int); static void nrn_state(_NrnThread*, _Memb_list*, int); static void nrn_cur(_NrnThread*, _Memb_list*, int); static void nrn_jacob(_NrnThread*, _Memb_list*, int); static int _ode_count(int); static void _ode_map(int, double**, double**, double*, Datum*, double*, int); static void _ode_spec(_NrnThread*, _Memb_list*, int); static void _ode_matsol(_NrnThread*, _Memb_list*, int); #define _cvode_ieq _ppvar[3]._i static void _ode_synonym(int, double**, Datum**); static void _ode_matsol_instance1(_threadargsproto_); /* connect range variables in _p that hoc is supposed to know about */ static const char *_mechanism[] = { "6.2.0", "cadyn", 0, 0, "ca_cadyn", 0, 0}; static Symbol* _ca_sym; extern Prop* need_memb(Symbol*); static void nrn_alloc(Prop* _prop) { Prop *prop_ion; double *_p; Datum *_ppvar; _p = nrn_prop_data_alloc(_mechtype, 7, _prop); /*initialize range parameters*/ _prop->param = _p; _prop->param_size = 7; _ppvar = nrn_prop_datum_alloc(_mechtype, 4, _prop); _prop->dparam = _ppvar; /*connect ionic variables to this model*/ prop_ion = need_memb(_ca_sym); nrn_check_conc_write(_prop, prop_ion, 1); nrn_promote(prop_ion, 3, 0); _ppvar[0]._pval = &prop_ion->param[1]; /* cai */ _ppvar[1]._pval = &prop_ion->param[3]; /* ica */ _ppvar[2]._pvoid = (void*)(&(prop_ion->dparam[0]._i)); /* iontype for ca */ } static void _initlists(); /* some states have an absolute tolerance */ static Symbol** _atollist; static HocStateTolerance _hoc_state_tol[] = { 0,0 }; static void _update_ion_pointer(Datum*); extern Symbol* hoc_lookup(const char*); extern void _nrn_thread_reg(int, int, void(*)(Datum*)); extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int)); extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***); extern void _cvode_abstol( Symbol**, double*, int); void _cadyn_reg() { int _vectorized = 1; _initlists(); ion_reg("ca", -10000.); _ca_sym = hoc_lookup("ca_ion"); register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 1); _mechtype = nrn_get_mechtype(_mechanism[1]); _nrn_setdata_reg(_mechtype, _setdata); _nrn_thread_reg(_mechtype, 2, _update_ion_pointer); hoc_register_prop_size(_mechtype, 7, 4); hoc_register_dparam_semantics(_mechtype, 0, "ca_ion"); hoc_register_dparam_semantics(_mechtype, 1, "ca_ion"); hoc_register_dparam_semantics(_mechtype, 2, "#ca_ion"); hoc_register_dparam_semantics(_mechtype, 3, "cvodeieq"); nrn_writes_conc(_mechtype, 0); hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol); hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist); hoc_register_synonym(_mechtype, _ode_synonym); hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc); ivoc_help("help ?1 cadyn /home/cluster/aleka/MainPath/Desktop/FSBC_model/Multicompartmental_Biophysical_models/mechanism/x86_64/cadyn.mod\n"); hoc_register_limits(_mechtype, _hoc_parm_limits); hoc_register_units(_mechtype, _hoc_parm_units); } static double FARADAY = 96485.3; static int _reset; static char *modelname = ""; static int error; static int _ninits = 0; static int _match_recurse=1; static void _modl_cleanup(){ _match_recurse=1;} static int _ode_spec1(_threadargsproto_); /*static int _ode_matsol1(_threadargsproto_);*/ static double *_temp1; static int _slist1[1], _dlist1[1]; static int state(_threadargsproto_); /*CVODE*/ static int _ode_spec1 (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {int _reset = 0; { drive_channel = - ( 10000.0 ) * ica / ( 2.0 * FARADAY * depth ) ; if ( drive_channel <= 0. ) { drive_channel = 0. ; } Dca = drive_channel / 18.0 + ( cainf - ca ) / taur * 11.0 ; cai = ca ; } return _reset; } static int _ode_matsol1 (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) { drive_channel = - ( 10000.0 ) * ica / ( 2.0 * FARADAY * depth ) ; if ( drive_channel <= 0. ) { drive_channel = 0. ; } Dca = Dca / (1. - dt*( ( ( ( ( - 1.0 ) ) ) / taur )*( 11.0 ) )) ; return 0; } /*END CVODE*/ static int state (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {int _reset=0; int error = 0; { drive_channel = - ( 10000.0 ) * ica / ( 2.0 * FARADAY * depth ) ; if ( drive_channel <= 0. ) { drive_channel = 0. ; } Dca = drive_channel / 18.0 + ( cainf - ca ) / taur * 11.0 ; cai = ca ; } return _reset;} static int _ode_count(int _type){ return 1;} static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) { double* _p; Datum* _ppvar; Datum* _thread; Node* _nd; double _v; int _iml, _cntml; _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; _nd = _ml->_nodelist[_iml]; v = NODEV(_nd); cai = _ion_cai; ica = _ion_ica; cai = _ion_cai; _ode_spec1 (_p, _ppvar, _thread, _nt); _ion_cai = cai; }} static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) { double* _p; Datum* _ppvar; int _i; _p = _pp; _ppvar = _ppd; _cvode_ieq = _ieq; for (_i=0; _i < 1; ++_i) { _pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i]; _cvode_abstol(_atollist, _atol, _i); } } static void _ode_synonym(int _cnt, double** _pp, Datum** _ppd) { double* _p; Datum* _ppvar; int _i; for (_i=0; _i < _cnt; ++_i) {_p = _pp[_i]; _ppvar = _ppd[_i]; _ion_cai = ca ; }} static void _ode_matsol_instance1(_threadargsproto_) { _ode_matsol1 (_p, _ppvar, _thread, _nt); } static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) { double* _p; Datum* _ppvar; Datum* _thread; Node* _nd; double _v; int _iml, _cntml; _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; _nd = _ml->_nodelist[_iml]; v = NODEV(_nd); cai = _ion_cai; ica = _ion_ica; cai = _ion_cai; _ode_matsol_instance1(_threadargs_); }} extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int); static void _update_ion_pointer(Datum* _ppvar) { nrn_update_ion_pointer(_ca_sym, _ppvar, 0, 1); nrn_update_ion_pointer(_ca_sym, _ppvar, 1, 3); } static void initmodel(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) { int _i; double _save;{ ca = ca0; { ca = cainf ; } } } static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){ double* _p; Datum* _ppvar; Datum* _thread; Node *_nd; double _v; int* _ni; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; #if CACHEVEC if (use_cachevec) { _v = VEC_V(_ni[_iml]); }else #endif { _nd = _ml->_nodelist[_iml]; _v = NODEV(_nd); } v = _v; cai = _ion_cai; ica = _ion_ica; cai = _ion_cai; initmodel(_p, _ppvar, _thread, _nt); _ion_cai = cai; nrn_wrote_conc(_ca_sym, (&(_ion_cai)) - 1, _style_ca); } } static double _nrn_current(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt, double _v){double _current=0.;v=_v;{ } return _current; } static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type) { double* _p; Datum* _ppvar; Datum* _thread; Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; #if CACHEVEC if (use_cachevec) { _v = VEC_V(_ni[_iml]); }else #endif { _nd = _ml->_nodelist[_iml]; _v = NODEV(_nd); } } } static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type) { double* _p; Datum* _ppvar; Datum* _thread; Node *_nd; int* _ni; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; #if CACHEVEC if (use_cachevec) { VEC_D(_ni[_iml]) += _g; }else #endif { _nd = _ml->_nodelist[_iml]; NODED(_nd) += _g; } } } static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type) { double* _p; Datum* _ppvar; Datum* _thread; Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml; double _dtsav = dt; if (secondorder) { dt *= 0.5; } #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; _nd = _ml->_nodelist[_iml]; #if CACHEVEC if (use_cachevec) { _v = VEC_V(_ni[_iml]); }else #endif { _nd = _ml->_nodelist[_iml]; _v = NODEV(_nd); } v=_v; { cai = _ion_cai; ica = _ion_ica; cai = _ion_cai; { euler_thread(1, _slist1, _dlist1, _p, state, _ppvar, _thread, _nt); if (secondorder) { int _i; for (_i = 0; _i < 1; ++_i) { _p[_slist1[_i]] += dt*_p[_dlist1[_i]]; }} } { } _ion_cai = cai; }} dt = _dtsav; } static void terminal(){} static void _initlists(){ double _x; double* _p = &_x; int _i; static int _first = 1; if (!_first) return; _slist1[0] = &(ca) - _p; _dlist1[0] = &(Dca) - _p; _first = 0; } #if defined(__cplusplus) } /* extern "C" */ #endif