/* Created by Language version: 6.2.0 */ /* NOT VECTORIZED */ #define NRN_VECTORIZED 0 #include #include #include #include "scoplib_ansi.h" #undef PI #define nil 0 #include "md1redef.h" #include "section.h" #include "nrniv_mf.h" #include "md2redef.h" #if METHOD3 extern int _method3; #endif #if !NRNGPU #undef exp #define exp hoc_Exp extern double hoc_Exp(double); #endif #define nrn_init _nrn_init__kadin #define _nrn_initial _nrn_initial__kadin #define nrn_cur _nrn_cur__kadin #define _nrn_current _nrn_current__kadin #define nrn_jacob _nrn_jacob__kadin #define nrn_state _nrn_state__kadin #define _net_receive _net_receive__kadin #define rates rates__kadin #define states states__kadin #define _threadargscomma_ /**/ #define _threadargsprotocomma_ /**/ #define _threadargs_ /**/ #define _threadargsproto_ /**/ /*SUPPRESS 761*/ /*SUPPRESS 762*/ /*SUPPRESS 763*/ /*SUPPRESS 765*/ extern double *getarg(); static double *_p; static Datum *_ppvar; #define t nrn_threads->_t #define dt nrn_threads->_dt #define gkabar _p[0] #define ik _p[1] #define gka _p[2] #define n _p[3] #define l _p[4] #define ek _p[5] #define Dn _p[6] #define Dl _p[7] #define _g _p[8] #define _ion_ek *_ppvar[0]._pval #define _ion_ik *_ppvar[1]._pval #define _ion_dikdv *_ppvar[2]._pval #if MAC #if !defined(v) #define v _mlhv #endif #if !defined(h) #define h _mlhh #endif #endif #if defined(__cplusplus) extern "C" { #endif static int hoc_nrnpointerindex = -1; /* external NEURON variables */ extern double celsius; /* declaration of user functions */ static void _hoc_alpl(void); static void _hoc_alpn(void); static void _hoc_betl(void); static void _hoc_betn(void); static void _hoc_rates(void); static int _mechtype; extern void _nrn_cacheloop_reg(int, int); extern void hoc_register_prop_size(int, int, int); extern void hoc_register_limits(int, HocParmLimits*); extern void hoc_register_units(int, HocParmUnits*); extern void nrn_promote(Prop*, int, int); extern Memb_func* memb_func; extern void _nrn_setdata_reg(int, void(*)(Prop*)); static void _setdata(Prop* _prop) { _p = _prop->param; _ppvar = _prop->dparam; } static void _hoc_setdata() { Prop *_prop, *hoc_getdata_range(int); _prop = hoc_getdata_range(_mechtype); _setdata(_prop); hoc_retpushx(1.); } /* connect user functions to hoc names */ static VoidFunc hoc_intfunc[] = { "setdata_kadin", _hoc_setdata, "alpl_kadin", _hoc_alpl, "alpn_kadin", _hoc_alpn, "betl_kadin", _hoc_betl, "betn_kadin", _hoc_betn, "rates_kadin", _hoc_rates, 0, 0 }; #define alpl alpl_kadin #define alpn alpn_kadin #define betl betl_kadin #define betn betn_kadin extern double alpl( double ); extern double alpn( double ); extern double betl( double ); extern double betn( double ); /* declare global and static user variables */ #define a0n a0n_kadin double a0n = 0.1; #define gml gml_kadin double gml = 1; #define gmn gmn_kadin double gmn = 0.39; #define lmin lmin_kadin double lmin = 2; #define linf linf_kadin double linf = 0; #define nmin nmin_kadin double nmin = 0.1; #define ninf ninf_kadin double ninf = 0; #define pw pw_kadin double pw = -1; #define q10 q10_kadin double q10 = 5; #define qq qq_kadin double qq = 5; #define tq tq_kadin double tq = -40; #define taun taun_kadin double taun = 0; #define taul taul_kadin double taul = 0; #define vhalfl vhalfl_kadin double vhalfl = -56; #define vhalfn vhalfn_kadin double vhalfn = -1; #define zetal zetal_kadin double zetal = 3; #define zetan zetan_kadin double zetan = -1.8; /* some parameters have upper and lower limits */ static HocParmLimits _hoc_parm_limits[] = { 0,0,0 }; static HocParmUnits _hoc_parm_units[] = { "vhalfn_kadin", "mV", "vhalfl_kadin", "mV", "a0n_kadin", "/ms", "zetan_kadin", "1", "zetal_kadin", "1", "gmn_kadin", "1", "gml_kadin", "1", "lmin_kadin", "ms", "nmin_kadin", "ms", "pw_kadin", "1", "tq_kadin", "mV", "qq_kadin", "mV", "taul_kadin", "ms", "taun_kadin", "ms", "gkabar_kadin", "mho/cm2", "ik_kadin", "mA/cm2", "gka_kadin", "mho/cm2", 0,0 }; static double delta_t = 0.01; static double l0 = 0; static double n0 = 0; static double v = 0; /* connect global user variables to hoc */ static DoubScal hoc_scdoub[] = { "vhalfn_kadin", &vhalfn_kadin, "vhalfl_kadin", &vhalfl_kadin, "a0n_kadin", &a0n_kadin, "zetan_kadin", &zetan_kadin, "zetal_kadin", &zetal_kadin, "gmn_kadin", &gmn_kadin, "gml_kadin", &gml_kadin, "lmin_kadin", &lmin_kadin, "nmin_kadin", &nmin_kadin, "pw_kadin", &pw_kadin, "tq_kadin", &tq_kadin, "qq_kadin", &qq_kadin, "q10_kadin", &q10_kadin, "ninf_kadin", &ninf_kadin, "linf_kadin", &linf_kadin, "taul_kadin", &taul_kadin, "taun_kadin", &taun_kadin, 0,0 }; static DoubVec hoc_vdoub[] = { 0,0,0 }; static double _sav_indep; static void nrn_alloc(Prop*); static void nrn_init(_NrnThread*, _Memb_list*, int); static void nrn_state(_NrnThread*, _Memb_list*, int); static void nrn_cur(_NrnThread*, _Memb_list*, int); static void nrn_jacob(_NrnThread*, _Memb_list*, int); static int _ode_count(int); static void _ode_map(int, double**, double**, double*, Datum*, double*, int); static void _ode_spec(_NrnThread*, _Memb_list*, int); static void _ode_matsol(_NrnThread*, _Memb_list*, int); #define _cvode_ieq _ppvar[3]._i static void _ode_matsol_instance1(_threadargsproto_); /* connect range variables in _p that hoc is supposed to know about */ static const char *_mechanism[] = { "6.2.0", "kadin", "gkabar_kadin", 0, "ik_kadin", "gka_kadin", 0, "n_kadin", "l_kadin", 0, 0}; static Symbol* _k_sym; extern Prop* need_memb(Symbol*); static void nrn_alloc(Prop* _prop) { Prop *prop_ion; double *_p; Datum *_ppvar; _p = nrn_prop_data_alloc(_mechtype, 9, _prop); /*initialize range parameters*/ gkabar = 0; _prop->param = _p; _prop->param_size = 9; _ppvar = nrn_prop_datum_alloc(_mechtype, 4, _prop); _prop->dparam = _ppvar; /*connect ionic variables to this model*/ prop_ion = need_memb(_k_sym); nrn_promote(prop_ion, 0, 1); _ppvar[0]._pval = &prop_ion->param[0]; /* ek */ _ppvar[1]._pval = &prop_ion->param[3]; /* ik */ _ppvar[2]._pval = &prop_ion->param[4]; /* _ion_dikdv */ } static void _initlists(); /* some states have an absolute tolerance */ static Symbol** _atollist; static HocStateTolerance _hoc_state_tol[] = { 0,0 }; static void _update_ion_pointer(Datum*); extern Symbol* hoc_lookup(const char*); extern void _nrn_thread_reg(int, int, void(*)(Datum*)); extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int)); extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***); extern void _cvode_abstol( Symbol**, double*, int); void _kadistin_reg() { int _vectorized = 0; _initlists(); ion_reg("k", -10000.); _k_sym = hoc_lookup("k_ion"); register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 0); _mechtype = nrn_get_mechtype(_mechanism[1]); _nrn_setdata_reg(_mechtype, _setdata); _nrn_thread_reg(_mechtype, 2, _update_ion_pointer); hoc_register_prop_size(_mechtype, 9, 4); hoc_register_dparam_semantics(_mechtype, 0, "k_ion"); hoc_register_dparam_semantics(_mechtype, 1, "k_ion"); hoc_register_dparam_semantics(_mechtype, 2, "k_ion"); hoc_register_dparam_semantics(_mechtype, 3, "cvodeieq"); hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol); hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist); hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc); ivoc_help("help ?1 kadin /home/cluster/aleka/MainPath/Desktop/FSBC_model/Multicompartmental_Biophysical_models/mechanism/x86_64/kadistin.mod\n"); hoc_register_limits(_mechtype, _hoc_parm_limits); hoc_register_units(_mechtype, _hoc_parm_units); } static double _zqt ; static int _reset; static char *modelname = "K-A channel from Klee Ficker and Heinemann"; static int error; static int _ninits = 0; static int _match_recurse=1; static void _modl_cleanup(){ _match_recurse=1;} static int rates(double); static int _ode_spec1(_threadargsproto_); /*static int _ode_matsol1(_threadargsproto_);*/ static int _slist1[2], _dlist1[2]; static int states(_threadargsproto_); /*CVODE*/ static int _ode_spec1 () {_reset=0; { rates ( _threadargscomma_ v ) ; Dn = ( ninf - n ) / taun ; Dl = ( linf - l ) / taul ; } return _reset; } static int _ode_matsol1 () { rates ( _threadargscomma_ v ) ; Dn = Dn / (1. - dt*( ( ( ( - 1.0 ) ) ) / taun )) ; Dl = Dl / (1. - dt*( ( ( ( - 1.0 ) ) ) / taul )) ; return 0; } /*END CVODE*/ static int states () {_reset=0; { rates ( _threadargscomma_ v ) ; n = n + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / taun)))*(- ( ( ( ninf ) ) / taun ) / ( ( ( ( - 1.0 ) ) ) / taun ) - n) ; l = l + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / taul)))*(- ( ( ( linf ) ) / taul ) / ( ( ( ( - 1.0 ) ) ) / taul ) - l) ; } return 0; } static int rates ( double _lv ) { double _la ; _la = alpn ( _threadargscomma_ _lv ) ; ninf = 1.0 / ( 1.0 + _la ) ; taun = betn ( _threadargscomma_ _lv ) / ( _zqt * a0n * ( 1.0 + _la ) ) ; if ( taun < nmin ) { taun = nmin ; } _la = alpl ( _threadargscomma_ _lv ) ; linf = 1.0 / ( 1.0 + _la ) ; taul = 0.26 * ( _lv + 50.0 ) ; if ( taul < lmin ) { taul = lmin ; } return 0; } static void _hoc_rates(void) { double _r; _r = 1.; rates ( *getarg(1) ); hoc_retpushx(_r); } double alpn ( double _lv ) { double _lalpn; double _lzeta ; _lzeta = zetan + pw / ( 1.0 + exp ( ( _lv - tq ) / qq ) ) ; _lalpn = exp ( 1.e-3 * _lzeta * ( _lv - vhalfn ) * 9.648e4 / ( 8.315 * ( 273.16 + celsius ) ) ) ; return _lalpn; } static void _hoc_alpn(void) { double _r; _r = alpn ( *getarg(1) ); hoc_retpushx(_r); } double betn ( double _lv ) { double _lbetn; double _lzeta ; _lzeta = zetan + pw / ( 1.0 + exp ( ( _lv - tq ) / qq ) ) ; _lbetn = exp ( 1.e-3 * _lzeta * gmn * ( _lv - vhalfn ) * 9.648e4 / ( 8.315 * ( 273.16 + celsius ) ) ) ; return _lbetn; } static void _hoc_betn(void) { double _r; _r = betn ( *getarg(1) ); hoc_retpushx(_r); } double alpl ( double _lv ) { double _lalpl; _lalpl = exp ( 1.e-3 * zetal * ( _lv - vhalfl ) * 9.648e4 / ( 8.315 * ( 273.16 + celsius ) ) ) ; return _lalpl; } static void _hoc_alpl(void) { double _r; _r = alpl ( *getarg(1) ); hoc_retpushx(_r); } double betl ( double _lv ) { double _lbetl; _lbetl = exp ( 1.e-3 * zetal * gml * ( _lv - vhalfl ) * 9.648e4 / ( 8.315 * ( 273.16 + celsius ) ) ) ; return _lbetl; } static void _hoc_betl(void) { double _r; _r = betl ( *getarg(1) ); hoc_retpushx(_r); } static int _ode_count(int _type){ return 2;} static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) { Datum* _thread; Node* _nd; double _v; int _iml, _cntml; _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; _nd = _ml->_nodelist[_iml]; v = NODEV(_nd); ek = _ion_ek; _ode_spec1 (); }} static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) { int _i; _p = _pp; _ppvar = _ppd; _cvode_ieq = _ieq; for (_i=0; _i < 2; ++_i) { _pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i]; _cvode_abstol(_atollist, _atol, _i); } } static void _ode_matsol_instance1(_threadargsproto_) { _ode_matsol1 (); } static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) { Datum* _thread; Node* _nd; double _v; int _iml, _cntml; _cntml = _ml->_nodecount; _thread = _ml->_thread; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; _nd = _ml->_nodelist[_iml]; v = NODEV(_nd); ek = _ion_ek; _ode_matsol_instance1(_threadargs_); }} extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int); static void _update_ion_pointer(Datum* _ppvar) { nrn_update_ion_pointer(_k_sym, _ppvar, 0, 0); nrn_update_ion_pointer(_k_sym, _ppvar, 1, 3); nrn_update_ion_pointer(_k_sym, _ppvar, 2, 4); } static void initmodel() { int _i; double _save;_ninits++; _save = t; t = 0.0; { l = l0; n = n0; { _zqt = pow( q10 , ( ( celsius - 24.0 ) / 10.0 ) ) ; rates ( _threadargscomma_ v ) ; n = ninf ; l = linf ; } _sav_indep = t; t = _save; } } static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){ Node *_nd; double _v; int* _ni; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; #if CACHEVEC if (use_cachevec) { _v = VEC_V(_ni[_iml]); }else #endif { _nd = _ml->_nodelist[_iml]; _v = NODEV(_nd); } v = _v; ek = _ion_ek; initmodel(); }} static double _nrn_current(double _v){double _current=0.;v=_v;{ { ik = gkabar * n * l * ( v - ek ) ; } _current += ik; } return _current; } static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type){ Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; #if CACHEVEC if (use_cachevec) { _v = VEC_V(_ni[_iml]); }else #endif { _nd = _ml->_nodelist[_iml]; _v = NODEV(_nd); } ek = _ion_ek; _g = _nrn_current(_v + .001); { double _dik; _dik = ik; _rhs = _nrn_current(_v); _ion_dikdv += (_dik - ik)/.001 ; } _g = (_g - _rhs)/.001; _ion_ik += ik ; #if CACHEVEC if (use_cachevec) { VEC_RHS(_ni[_iml]) -= _rhs; }else #endif { NODERHS(_nd) -= _rhs; } }} static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type){ Node *_nd; int* _ni; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; #if CACHEVEC if (use_cachevec) { VEC_D(_ni[_iml]) += _g; }else #endif { _nd = _ml->_nodelist[_iml]; NODED(_nd) += _g; } }} static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type){ Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml; #if CACHEVEC _ni = _ml->_nodeindices; #endif _cntml = _ml->_nodecount; for (_iml = 0; _iml < _cntml; ++_iml) { _p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml]; _nd = _ml->_nodelist[_iml]; #if CACHEVEC if (use_cachevec) { _v = VEC_V(_ni[_iml]); }else #endif { _nd = _ml->_nodelist[_iml]; _v = NODEV(_nd); } v=_v; { ek = _ion_ek; { error = states(); if(error){fprintf(stderr,"at line 75 in file kadistin.mod:\n: ik = gkabar*n*l*(v+70)\n"); nrn_complain(_p); abort_run(error);} } }} } static void terminal(){} static void _initlists() { int _i; static int _first = 1; if (!_first) return; _slist1[0] = &(n) - _p; _dlist1[0] = &(Dn) - _p; _slist1[1] = &(l) - _p; _dlist1[1] = &(Dl) - _p; _first = 0; }