COMMENT //****************************// // Created by Alon Polsky // // apmega@yahoo.com // // 2010 // //****************************// based on Sun et al 2006 Modified 2015 by Robert Egger to include facilitation variable as modeled by Varela et al. 1997 ENDCOMMENT TITLE GABAA synapse activated by the network NEURON { POINT_PROCESS gaba_syn NONSPECIFIC_CURRENT i RANGE i,ggaba RANGE decaygaba,dgaba,taudgaba RANGE facilgaba,fgaba,taufgaba :RANGE R,D RANGE risetime,decaytime,e } PARAMETER { e= -60.0 (mV) risetime=1 (ms) :2 decaytime=20(ms) :40 v (mV) taudgaba=200 (ms) decaygaba=0.8 taufgaba=200 (ms) facilgaba=0.0 } ASSIGNED { i (nA) ggaba factor : conductance normalization factor } STATE { dgaba fgaba R D } INITIAL { LOCAL tp dgaba=1 fgaba=1 R=0 D=0 ggaba=0 tp = (risetime*decaytime)/(decaytime - risetime) * log(decaytime/risetime) factor = -exp(-tp/risetime) + exp(-tp/decaytime) factor = 1/factor } BREAKPOINT { SOLVE state METHOD cnexp ggaba=D-R i=(1e-3)*ggaba*(v-e) } NET_RECEIVE(weight) { R = R + factor*weight*dgaba*fgaba D = D + factor*weight*dgaba*fgaba dgaba = dgaba* decaygaba fgaba = fgaba + facilgaba } DERIVATIVE state { R'=-R/risetime D'=-D/decaytime dgaba'=(1-dgaba)/taudgaba fgaba'=(1-fgaba)/taufgaba }