objref somaVm, somaT, somaD1, somaD2, abdVm, abdT, abdD1, abdD2, nabdVm, nabdT, nabdD1, nabdD2, fnabd, fabd, fsoma, fsomaSum, fabdSum, fnabdSum objref fais, faisSum, aisVm, aisD1, aisD2, fISI proc variable_length(){ somaVm = new Vector() somaT = new Vector() somaD1 = new Vector() somaD2 = new Vector() abdVm = new Vector() abdT = new Vector() abdD1 = new Vector() abdD2 = new Vector() nabdVm = new Vector() nabdT = new Vector() nabdD1 = new Vector() nabdD2 = new Vector() fsomaSum = new File() fabdSum = new File() fnabdSum = new File() fsoma = new File() fabd = new File() fnabd = new File() fISI = new File() chdir("data") strdef somaSum sprint (somaSum, "%s", "Variable_AIS_Cell_4_soma_data.txt") fsomaSum.wopen(somaSum) fsomaSum.printf("%s\t %s\t %s\t %s\t %s\t %s\t %s\t %s\t %s\t %s\t %s\t %s\t", "Parameter", "Na/K SD", "K_ais ", "Na_ais", "ABD lenght", "AIS length", "threshold index", "AP threshold", "AP amplitude", "AP half-width", "IS dv2", "SD dv2") fsomaSum.close strdef abdSum sprint (abdSum, "%s", "Variable_AIS_Cell_4_ABD_data.txt") fabdSum.wopen(abdSum) fabdSum.printf("%s\t %s\t %s\t %s\t %s\t %s\t %s\t %s\t %s\t %s\t %s\t %s\t", "Parameter", "Na/K SD", "K_ais ", "Na_ais", "ABD lenght", "AIS length", "threshold index", "AP threshold", "AP amplitude", "AP half-width", "IS dv2", "SD dv2") fabdSum.close strdef nabdSum sprint (nabdSum, "%s", "Variable_AIS_Cell_4_nABD_data.txt") fnabdSum.wopen(nabdSum) fnabdSum.printf("%s\t %s\t %s\t %s\t %s\t %s\t %s\t %s\t %s\t %s\t %s\t %s\t", "Parameter", "Na/K SD", "K_ais ", "Na_ais", "ABD lenght", "AIS length", "threshold index", "AP threshold", "AP amplitude", "AP half-width", "IS dv2", "SD dv2") fnabdSum.close strdef ISISum sprint (ISISum, "%s", "ISI_DATA_Cell_4.txt") fISI.wopen(ISISum) fISI.printf("%s\t %s\t %s\t %s\t %s\t %s\t ", "Parameter", "AIS length","ABD length","Na SD", "Na AIS", "ISI") fISI.close for j=1, 5{ //Loop changing AIS length SIprox.L = j*10 SIdistal.L = 10 for k=2, 4{ //loop changing gbar Na in the sd { forsec all { gbar_Na12 = k*25 gbar_kdrDA= k*50 } SIprox.gbar_Na12= 5000 SIdistal.gbar_Na12 = 5000 SIprox.gbar_kdrDA = 5000 SIdistal.gbar_kdrDA = 5000 axon.gbar_Na12=400 axon.gbar_kdrDA=400 } abd_length = dend1.L + dend1[1].L + dend1[2].L ais_length = SIprox.L + SIdistal.L print "ABD_length is ", abd_length print "AIS_length is ", ais_length print "AIS Na+ density is ", SIprox.gbar_Na12 print "SD Na+ density is ", dend1.gbar_Na12 // recording Vm and time in corresponding vectors geom_nseg to modify nbr of segments according to dend length geom_nseg() diam_seg() init(v_init) soma somaT.record(&t) soma somaVm.record(&v(0.5)) dend1[1] abdVm.record(&v(0.5)) dend1[1] abdT.record(&t) dend1_1[1] nabdVm.record(&v(0.005)) dend1_1[1] nabdT.record(&t) run() somaD1.deriv(somaVm, dt) somaD2.deriv(somaD1, dt) abdD1.deriv(abdVm, dt) abdD2.deriv(abdD1, dt) nabdD1.deriv(nabdVm, dt) nabdD2.deriv(nabdD1, dt) freqmeter() print "controle bug1" } print "controle bug2" } print "controle bug3" quit() }