TITLE nap COMMENT Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008) ENDCOMMENT NEURON { SUFFIX nap USEION na READ ena WRITE ina RANGE gbar, timestauh, timestaum, shifttaum, shifttauh, thegna GLOBAL minf, mtau } PARAMETER { gbar = .0052085 (mho/cm2) :q10m=3.1 :q10h=2.3 timestauh=1 timestaum=1 shifttaum=1 shifttauh=1 eNa = 55 (mV) :Golomb et al. ena (mV) : must be explicitly def. in hoc celsius (degC) v (mV) } UNITS { (mA) = (milliamp) (mV) = (millivolt) (pS) = (picosiemens) (um) = (micron) } ASSIGNED { ina (mA/cm2) thegna (mho/cm2) minf :hinf mtau (ms) :htau (ms) } STATE { m } UNITSOFF BREAKPOINT { SOLVE states METHOD cnexp mtau = 1 minf = (1/(1+exp(-(v+52.3)/6.8))) :midpoint -56.3, slope 7.4 thegna =gbar*m ina = thegna * (v - eNa) } INITIAL { mtau = 1 minf = (1/(1+exp(-(v+52.3)/6.8))) :midpoint - 52.3 slope 6.8 5.5 m=minf } DERIVATIVE states { mtau = 1 minf = (1/(1+exp(-(v+52.3)/6.8))) :midpoint - 52.3 (47) slope 6.8 m' = (minf-m)/mtau } UNITSON