COMMENT Author: Mark Cembrowski, 2015 This is an extension of the Exp2Syn class to incorporate tracking of the specific features of different excitatory synapses. Specifically, this includes whether a synapse has an isOn attribute, which acts as a switch on whether the synapse is on (if = 0, conductance is always = 0; if = 1, synapse behaves as normal). As background, the Exp2Syn features are described as: Two state kinetic scheme synapse described by rise time tau1, and decay time constant tau2. The normalized peak condunductance is 1. Decay time MUST be greater than rise time. The solution of A->G->bath with rate constants 1/tau1 and 1/tau2 is A = a*exp(-t/tau1) and G = a*tau2/(tau2-tau1)*(-exp(-t/tau1) + exp(-t/tau2)) where tau1 < tau2 If tau2-tau1 -> 0 then we have a alphasynapse. and if tau1 -> 0 then we have just single exponential decay. The factor is evaluated in the initial block such that an event of weight 1 generates a peak conductance of 1. Because the solution is a sum of exponentials, the coupled equations can be solved as a pair of independent equations by the more efficient cnexp method. ENDCOMMENT NEURON { POINT_PROCESS excSyn RANGE tau1, tau2, e, i NONSPECIFIC_CURRENT i RANGE g RANGE xEff RANGE isOn } UNITS { (nA) = (nanoamp) (mV) = (millivolt) (uS) = (microsiemens) } PARAMETER { tau1=.2 (ms) <1e-9,1e9> tau2 = 2.5 (ms) <1e-9,1e9> e=0 (mV) xEff=-1 isOn=0 } ASSIGNED { v (mV) i (nA) g (uS) factor } STATE { A (uS) B (uS) } INITIAL { LOCAL tp if (tau1/tau2 > .9999) { tau1 = .9999*tau2 } A = 0 B = 0 tp = (tau1*tau2)/(tau2 - tau1) * log(tau2/tau1) factor = -exp(-tp/tau1) + exp(-tp/tau2) factor = 1/factor } BREAKPOINT { SOLVE state METHOD cnexp g = (B - A)*isOn i = g*(v - e) } DERIVATIVE state { A' = -A/tau1 B' = -B/tau2 } NET_RECEIVE(weight (uS)) { A = A + weight*factor B = B + weight*factor }