Model files in the NEURON simulation environment (v8.0) from the paper


"Analysis of age-dependent alterations in excitability properties of CA1 pyramidal neurons in an APPPS1 model of Alzheimer's disease"

by Paola Vitale, Ana Rita Salgueiro-Pereira, Carmen Alina Lupascu, Rosanna Migliore, Michele Migliore and Helene Marie


Frontiers in Aging Neuroscience 2021



        Compile the mod files with mknrndll (mswin or graphical mac) or nrnivmodl (unix/linux)).

        Start the simulation by (unix/linux) typing on the command line: nrngui Figure3D.hoc or (mac os x) drag and dropping the Figure3D.hoc file on the nrngui icon or (mswin) double clicking on the Figure3D.hoc file.

        After selecting the experimental trace (on ''exp'' panel) and the corresponding phenotype (on ''model'' panel), simulation will reproduce the traces in Figure 3D of the paper.

        To test more parameters the user should could also handling the ''values'' panel and perform his own simulation.


Example: clicking on "exp -0.15 WT-10m" and "WT-10m" and running the simulation the window should produce the following graph:



Questions on how to use this model should be directed to or to

All electrophysiological traces and morphologies used for the models are available at the Human Brain Project collab

Access to this resource requires free user registration at