TITLE Calcium decay : as described in Bhalla and Bower, J. Neurophysiol. 69:1948-1983 (1993) : Andrew Davison, The Babraham Institute, 1998 : partially based on cadecay.mod by Alain Destexhe, Salk Institute 1995. INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms) } NEURON{ SUFFIX cad USEION ca READ ica, cai WRITE cai RANGE ica, channel_flow, depth, B GLOBAL tau, cainf } UNITS { (mA) = (milliamp) (mV) = (millivolt) (molar) = (1/liter) (mM) = (millimolar) (um) = (micron) } CONSTANT { FARADAY = 96154 (coul) :FARADAY = 93149 (coul) : moles do not appear in units : note this value is chosen to fit with : Genesis } PARAMETER { dt (ms) depth = 1 (um) : shell within which cai is calculated : to match Bhalla and Bower 1993 set : depth = diam/4 for each compartment tau = 10 (ms) : cai decay constant cainf = 1e-5 (mM) : baseline calcium concentration ica (mA/cm2) } STATE { cai (mM) } INITIAL { cai = cainf } ASSIGNED { channel_flow (mM/ms) B (mM cm2/ms/mA) } BREAKPOINT { SOLVE state METHOD cnexp } DERIVATIVE state { B = -(1e4)/(2*FARADAY*depth) channel_flow = B*ica if (channel_flow <= 0.0 ) { channel_flow = 0.0 } : one way flow in channel cai' = channel_flow - (cai - cainf)/tau }