TITLE Second Sodium transient current for Traub RD et al 2005 COMMENT This sodium current was present in Gabaergic interneurons and spiny stellate cells in the Traub et al 2005 model: deepaxax, deepbask, deepLTS, spinstell, supaxax, supbask, supLTS, nRT Tom Morse 3/8/2006 Modified from the Implementation of naf by Maciej Lazarewicz 2003 (mlazarew@seas.upenn.edu) made for RD Traub, J Neurophysiol 89:909-921, 2003 ENDCOMMENT INDEPENDENT { t FROM 0 TO 1 WITH 1 (ms) } UNITS { (mV) = (millivolt) (mA) = (milliamp) } NEURON { SUFFIX naf2 USEION na READ ena WRITE ina RANGE gbar, ina,m, h, df, fastNa_shift, a, b, c, d, minf, mtau } PARAMETER { fastNa_shift = 0 : orig -3.5 (mV) a = 0 (1) b = 0 (1) c = 0 (1) d = 0 (1) gbar = 0.0 (mho/cm2) v (mV) ena (mV) } ASSIGNED { ina (mA/cm2) minf hinf (1) mtau (ms) htau (ms) df (mV) } STATE { m h } BREAKPOINT { SOLVE states METHOD cnexp ina = gbar * m * m * m * h * ( v - ena ) df = v - ena } INITIAL { settables( v ) m = minf m = 0 h = hinf } DERIVATIVE states { settables( v ) m' = ( minf - m ) / mtau h' = ( hinf - h ) / htau } UNITSOFF PROCEDURE settables(v1(mV)) { TABLE minf, hinf, mtau, htau FROM -120 TO 40 WITH 641 minf = 1 / ( 1 + exp( ( - ( v1 + fastNa_shift ) - 38 ) / 10 ) ) if( ( v1 + fastNa_shift ) < -30.0 ) { mtau = 0.0125 + 0.1525 * exp( ( ( v1 + fastNa_shift ) + 30 ) / 10 ) } else{ mtau = 0.02 + a + (0.145+ b) * exp( ( - ( v1 + fastNa_shift +d ) - 30 ) / (10+c) ) } : hinf, and htau are shifted 3.5 mV comparing to the paper hinf = 1 / ( 1 + exp( ( ( v1 + fastNa_shift * 0 ) + 58.3 ) / 6.7 ) ) htau = 0.225 + 1.125 / ( 1 + exp( ( ( v1 + fastNa_shift * 0 ) + 37 ) / 15 ) ) } UNITSON