This is the readme for a model recreated from the publication: 

Baker MD (2005) Protein kinase C mediates up-regulation of
tetrodotoxin-resistant, persistent Na+ current in rat and mouse
sensory neurones. J Physiol 567:851-67


The tetrodotoxin-resistant (TTX-r) persistent Na+ current, attributed
to NaV1.9, was recorded in small (<25 um apparent diameter) dorsal
root ganglion (DRG) neurones cultured from P21 rats and from adult
wild-type and NaV1.8 null mice. In conventional whole-cell recordings
intracellular GTP-gamma-S caused current up-regulation, an effect
inhibited by the PKC pseudosubstrate inhibitor, PKC19-36. The current
amplitude was also up-regulated by 25 uM intracellular
1-oleoyl-2-acetyl-sn-glycerol (OAG) consistent with PKC
involvement. In perforated-patch recordings, phorbol 12-myristate
13-acetate (PMA) up-regulated the current, whereasmembrane-permeant
activators of protein kinaseA (PKA) werewithout effect.PGE2 did not
acutely up-regulate the current. Conversely, both PGE2 and PKA
activation up-regulated the major TTX-r Na+ current,
NaV1.8. Extracellular ATP up-regulated the persistent current with an
average apparent Kd near 13 uM, possibly consistent with P2Y receptor
activation.  Numerical simulation of the up-regulation qualitatively
reproduced changes in sensory neurone firing properties. The
activation of PKC appears to be a necessary step in the GTP-dependent
up-regulation of persistent Na+ current.


The model contains all the mod files from the currents used in the
paper.  To run auto-launch from modeldb or download and extract the
archive and compile the mod files by

Run mknrndll in the directory created on expanding the archive.


Type the command "nrnivmodl" in the directory created on expanding the


Drag and drop the folder created on expanding the archive onto the
mknrndll icon.


Then run the model by

Double clicking on the mosinit.hoc file in the folder expanded from
the archive.


Type the command "nrngui mosinit.hoc" in the folder expanded from
the archive.


Drag and drop the mosinit.hoc from the folder expanded from
the archive onto the nrngui icon.


Once the model is running press the "Fig 8" button.  When the
simulation completes you should see the figures:


Questions about the implementation of the model can be directed to Tom
Morse, questions about the paper to Mark Baker.

February 15th, 2010: Bug fix by Marcus Petersson who noticed in ks.mod
the power of the gating variable is 1 not 4.