This model of cardiac sarcomere dynamics linked to calcium kinetics is implemented and
modified for Neuron by Francois E. Gannier and Claire O. Malecot 
	from University of Tours - FRANCE
	Physiologie des Cellules Cardiaques et Vasculaires
	email address:

It is based on the paper by :
Negroni JA & Lascano EC (1996) A cardiac muscle model relating sarcomere 
dynamics to calcium kinetics. J Mol Cell Cardio 28:915-929 [PubMed]

this is a now classic model of contraction which has been added in some recent models 
(eg : kyoto model (2003), Okada model (2005))

it uses a four-state combination to show the relation between C-Troponin, calcium,
cross-bridges and Force.

The orginal model was modified to allow several stimuli with self-chosen frequency.
(This allows to reproduce a staircase phenomenom)
To run the simulation auto-launch the model from modeldb or download
and extract the archive and then compile the mod files under:

type nrnivmodl in the NegroniLascano folder and then
nrngui mosinit.hoc

run mknrndll and then double click on mosinit.hoc


Drag and drop the NegroniLascano folder onto the mknrndll icon.  Drag
and drop the mosinit.hoc file onto the nrngui icon.

Once the simulation starts it recreates a figure similar to Fig. 2 (shown as three 
panels for clarity)& 3 of the original paper.

Figure 2 & 3