/*******Cerebellar Golgi Cell Model with Na+/K+ ATPase********** Developers: Fabio M Simoes de Souza & E De Schutter Work Progress: July 2009 - Dec 2009 Developed At: Okinawa Institute of Science and Technology Computational Neuroscience Unit Okinawa - Japan Model Published in: Botta P, Simoes de Souza F, Sangrey T, De Schutter E, Valenzuela F (2010) Alcohol excites cerebellar Golgi cells by inhibiting the Na+/K+ ATPase. Neuropsychopharmacology 35: 1984-1996. This script is a modification from a previous published GoC model (Solinas et al., 2007). A Na+/K+ ATPase and ionic concentration pools for Na+, K+, Ca2+ were incorporated into the soma of the model. The equations that simulated the Na+/K+ ATPase are described in Table S10 of Takeuchi et al. (2006) Abstract Alcohol Excites Cerebellar Golgi Cells by Inhibiting the Na+/K+ ATPase Patch-clamp in cerebellar slices and computer modeling show that ethanol excites Golgi cells by inhibiting the Na+/K+ ATPase. In particular, voltage-clamp recordings of Na+/K+ ATPase currents indicated that ethanol partially inhibits this pump and this effect could be mimicked by low concentrations of the Na+/K+ ATPase blocker ouabain. The partial inhibition of Na+/K+ ATPase in a computer model of the Golgi cell reproduced these experimental findings that established a novel mechanism of action of ethanol on neural excitability. Reference: Botta P, de Souza FM, Sangrey T, De Schutter E, Valenzuela CF (2010) Alcohol excites cerebellar Golgi cells by inhibiting the na(+)-k(+) ATPase. Neuropsychopharmacology 35:1984-96 Usage instructions: Auto-launch from ModelDB or download and extract the archive. Then under: ---- MSWIN run mknrndll, cd to the archive and make the nrnmech.dll. Then double click on the mosinit.hoc file. ---- MAC OS X Drag and drop the Golgi_cell_NaKATPAse folder onto the mknrndll icon. Drag and drop the mosinit.hoc file onto the nrngui icon. ---- Linux/Unix Change directory to the Golgi_cell_NaKATPAse folder. run nrnivmodl. Then type nrngui mosinit.hoc ---- Once the simulation is started click the button labeled "Figure 7g from Botta et al. 2010" The simulation will produce a result similar to figure 7g from the paper: 20140305 An update was made to pump.mod to make the model current with a new version of NEURON (hg revision 1027) while retaining compatibility with old versions. The number of parameters in settables was made to match the number of the calling instances.