/*******Cerebellar Golgi Cell Model with Na+/K+ ATPase**********

Developers:    Fabio M Simoes de Souza & E De Schutter

Work Progress: July 2009 - Dec 2009

Developed At:  Okinawa Institute of Science and Technology
               Computational Neuroscience Unit
               Okinawa - Japan
	       
Model Published in: 

             Botta P, Simoes de Souza F, Sangrey T, De Schutter E,
             Valenzuela F (2010) Alcohol excites cerebellar Golgi
             cells by inhibiting the Na+/K+ ATPase.
             Neuropsychopharmacology 35: 1984-1996.

This script is a modification from a previous published GoC model
(Solinas et al., 2007). A Na+/K+ ATPase and ionic concentration pools
for Na+, K+, Ca2+ were incorporated into the soma of the model.
The equations that simulated the Na+/K+ ATPase are described in Table
S10 of Takeuchi et al. (2006)

Abstract

Alcohol Excites Cerebellar Golgi Cells by Inhibiting the Na+/K+ ATPase
Patch-clamp in cerebellar slices and computer modeling show that
ethanol excites Golgi cells by inhibiting the Na+/K+ ATPase. In
particular, voltage-clamp recordings of Na+/K+ ATPase currents
indicated that ethanol partially inhibits this pump and this effect
could be mimicked by low concentrations of the Na+/K+ ATPase blocker
ouabain. The partial inhibition of Na+/K+ ATPase in a computer model
of the Golgi cell reproduced these experimental findings that
established a novel mechanism of action of ethanol on neural
excitability.

Reference: Botta P, de Souza FM, Sangrey T, De Schutter E, Valenzuela
CF (2010) Alcohol excites cerebellar Golgi cells by inhibiting the
na(+)-k(+) ATPase. Neuropsychopharmacology 35:1984-96

Usage instructions:

Auto-launch from ModelDB or download and extract the archive.  Then
under:

----
MSWIN

run mknrndll, cd to the archive and make the nrnmech.dll.  Then double
click on the mosinit.hoc file.

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MAC OS X

Drag and drop the Golgi_cell_NaKATPAse folder onto the mknrndll icon.
Drag and drop the mosinit.hoc file onto the nrngui icon.

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Linux/Unix

Change directory to the Golgi_cell_NaKATPAse folder. run
nrnivmodl. Then type nrngui mosinit.hoc

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Once the simulation is started click the button labeled 
"Figure 7g from Botta et al. 2010" The simulation will produce a
result similar to figure 7g from the paper:

screenshot

20140305 An update was made to pump.mod to make the model current with
a new version of NEURON (hg revision 1027) while retaining
compatibility with old versions. The number of parameters in settables
was made to match the number of the calling instances.