Neuron files for the paper: Halnes, Augustinaite, Heggelund, Einevoll, Migliore (2011) A Multi-Compartment Model for Interneurons in the Dorsal Lateral Geniculate Nucleus. PLoS Comp. Biol. 7: e1002160 The model was adapted to experimental Current-Clamp data from two interneurons in the dLGN (IN1 and IN2). Two respective parameterizations were obtained (P1 & P2). Each parameterization qualitatively reproduces the response pattern of the respective neuron under 8 different experimental conditions. Furthermore, quantitative data on #APs elicited as a function of injected current was reproduced. These model files were supplied by Geir Halnes. Use: These files require the NEURON simulator available from www.neuron.yale.edu. After installing NEURON either auto-launch (may require configuring your browser) or download and extract this archive and compile the mod files (mswin: run mknrndll, mac: drag and drop the archive folder onto mknrndll, linux/unix: type "nrnivmodl" in a shell in the archive folder). Start the simulation (mswin: double click the mosinit.hoc file, mac: drag and drop the mosinit.hoc file onto nrngui, linux/unix: type "nrngui mosinit.hoc" in the archive folder). Once the simulation starts click the buttons with the following options: P1: MP = -63 Opens the model with Parameterization 1. Model for interneuron with resting potential at -63mV. The user can change the amplitude of the injected current (-150pA, -25pA, 20pA, 55pA, 60pA, 65pA, 70pA used in paper) The 55pA default setting reproduces the fourth trace in figure 4 A1 (when Init & Run is clicked): P1: HP = -57 Opens the model with Parameterization 1. Uses a continous weak current injection (22pA) to obtain a holding potential of -57mV. Strong hyperpolarizing current injection (-150pA) is then followed by a rebound burst. Here Init & Run click will produce figure 4 B1: P2: MP = -69 Opens the model with Parameterization 2. Model for interneuron with resting potential at -69mV. The user can change the amplitude of the injected current (-150pA, -25pA, 20pA, 40pA, 50pA, 60pA, 70pA used in paper) Here the setting of 40pA will reproduce the 4th trace in Fig 4 A2: P2: HP = -58 Opens the model with Parameterization Uses a continous weak current injection (12pA) to obtain a holding potential of -58mV. Strong hyperpolarizing current injection (-150pA) is followed by a subthreshold rebound response, figure 4 B2: 20130530 update by Geir to include a missing parameter value in INmodel.hoc. Doesn't change results if used as-is.