Software for fitting Hodgkin-Huxley Models to Voltage-Clamp data
This is version 1.7 released May 21,
NEUROFIT is a program which fits Hodgkin-Huxley models to voltage-clamp data.
NEUROFIT is available freely online at
NEUROFIT should run on any Microsoft Windows environment.
Bug reports and comments should be sent to
- Install NEUROFIT by simply unzipping the file
NEUROFITInstall.zip somewhere; it doesn't matter
where. You will get a directory called
- To run NEUROFIT, launch
NEUROFIT.exe in the
- Usage instructions and a tutorial are available from within NEUROFIT by
clicking on "Help".
- Register via emailto receive email notification whenever this software is updated.
The code which performs the nonlinear least squares fitting is a C
translation and adaptation of an implementation of the
Levenberg-Marquardt algorithm written in Fortran and freely available from the
Netlib Mathematical Software Repository
The translation was done by Howie Kuo and adaptations to allow for linear
inequality constraints were completed by
Allan Willms. The remainder of the code for the nonlinear fitting
algorithm, and all of the code for the quick fit linear algorithm was
written by Allan Willms.
The user interface was written by Greg Ewing and Allan Willms using
the Python interpretive language
(freely available from
A Python interpreter is bundled as part of the NEUROFIT package.
Support for this project has been given by:
- The University of Canterbury, Internal Research Grant U6322.
- The Royal Society of New Zealand, International Science and Technology
Linkages Fund, NZ/USA Co-operative Science Programme, grants 99-CSP-49-WILL
- The laboratory of Prof. R.M. Harris-Warrick, Department of Neurobiology
and Behavior, Cornell University, Ithaca,
This software is introduced and its convergence properties are described
NEUROFIT: software for fitting Hodgkin-Huxley models to voltage-clamp
J. Neurosci. Meth. 121 (2002), 139-150.
The nonlinear fitting algorithm is described in:
A.R. Willms, D.J. Baro, R.M. Harris-Warrick, and
An improved parameter estimation method for Hodgkin-Huxley
J. Comput. Neurosci. 6 (1999), 145-168.
The quick fit algorithm is based on the one described in:
T.I. T�th and V. Crunelli, A numerical procedure to estimate
kinetic and steady-state characteristics of inactivating ionic
currents, J. Neurosci. Meth. 63 (1995), 1-12.