NEUROFIT
Software for fitting HodgkinHuxley Models to VoltageClamp data
Allan Willms


About NEUROFIT
This is version 1.7 released May 21,
2004.
Release Notes.
NEUROFIT is a program which fits HodgkinHuxley models to voltageclamp data.
NEUROFIT is available freely online at
NEUROFIT should run on any Microsoft Windows environment.
Bug reports and comments should be sent to
Allan Willms.
Installation Instructions
 Download
NEUROFITInstall.zip
(2.8 MB)
 Install NEUROFIT by simply unzipping the file
NEUROFITInstall.zip
somewhere; it doesn't matter
where. You will get a directory called NEUROFIT
.
 To run NEUROFIT, launch
NEUROFIT.exe
in the
NEUROFIT
directory.
 Usage instructions and a tutorial are available from within NEUROFIT by
clicking on "Help".
 Register via emailto receive email notification whenever this software is updated.
Acknowledgements
The code which performs the nonlinear least squares fitting is a C
translation and adaptation of an implementation of the
LevenbergMarquardt algorithm written in Fortran and freely available from the
Netlib Mathematical Software Repository
(lmder.f).
The translation was done by Howie Kuo and adaptations to allow for linear
inequality constraints were completed by
Allan Willms. The remainder of the code for the nonlinear fitting
algorithm, and all of the code for the quick fit linear algorithm was
written by Allan Willms.
The user interface was written by Greg Ewing and Allan Willms using
the Python interpretive language
(freely available from
http://python.org/
).
A Python interpreter is bundled as part of the NEUROFIT package.
Support for this project has been given by:
 The University of Canterbury, Internal Research Grant U6322.
 The Royal Society of New Zealand, International Science and Technology
Linkages Fund, NZ/USA Cooperative Science Programme, grants 99CSP49WILL
and 01CSP44WILL.
 The laboratory of Prof. R.M. HarrisWarrick, Department of Neurobiology
and Behavior, Cornell University, Ithaca,
USA.
References
This software is introduced and its convergence properties are described
in:
A.R. Willms,
NEUROFIT: software for fitting HodgkinHuxley models to voltageclamp
data,
J. Neurosci. Meth. 121 (2002), 139150.
The nonlinear fitting algorithm is described in:
A.R. Willms, D.J. Baro, R.M. HarrisWarrick, and
J. Guckenheimer,
An improved parameter estimation method for HodgkinHuxley
models,
J. Comput. Neurosci. 6 (1999), 145168.
The quick fit algorithm is based on the one described in:
T.I. T�th and V. Crunelli, A numerical procedure to estimate
kinetic and steadystate characteristics of inactivating ionic
currents, J. Neurosci. Meth. 63 (1995), 112.