Simulation of single-compartment Hodgkin-Huxley models for different classes of cortical neurons The models are described in: Pospischil, M., Toledo-Rodriguez, M., Monier, C., Piwkowska, Z., Bal, T., Fregnac, Y., Markram, H. and Destexhe, A. Minimal Hodgkin-Huxley type models for different classes of cortical and thalamic neurons. Biological Cybernetics 99: 427-441, 2008. Intrinsic currents: INa, IKd for action potentials, IM for spike-frequency adaptation, ICaL for high-threshold calcium current, ICaT for the low-threshold calcium current, intracellular calcium dynamics. demo_PY_RS.oc : simplified model of the "regular-spiking" neuron demo_IN_FS.oc : simplified model of the "fast-spiking" interneuron demo_PY_IB.oc : simplified model of the "intrinsically bursting" neuron demo_PY_IBR.oc : simplified model of the "repetive bursting" neuron demo_PY_LTS.oc : simplified model of the "low-threshold spike" neurons Usage: ------ Simply auto-launch from ModelDB (after NEURON is installed) or download and extract the archive. Then under linux/unix: ----------- cd to the extracted folder. Type at the shell prompt: nrnivmodl nrngui mosinit.hoc MAC OS X: --------- Drag and drop the extracted folder onto the mknrndll icon. Drag and drop the mosinit.hoc file onto the nrngui icon. mswin: ------ Run mknrndll and cd to the extracted folder. Select to make the nrnmech.dll. Use windows explorer to view the contents of the expanded folder from the archive. Double click on the mosinit.hoc file. Once the simulation is started: ------------------------------- Click on a button to select a cell. Reposition the windows and press the Init & Run button. For example selecting Bursting Pyramidal Cell and then Init & Run should produce a figure like figure 5B from the paper: 20111102 The file IL_gutnick.mod was updated to use derivimplicit in the solver. See http://www.neuron.yale.edu/phpBB/viewtopic.php?f=28&t=592 for details. 20120216 the files IM_cortex.mod, IT_huguenard.mod, and cadecay_destexhe.mod had solver methods updated from euler to cnexp, cnexp, and derivimplicit respectively. The IL_gutnick.mod was changed from derivimplicit to cnexp. See www.neuron.yale.edu phpBB link above.