Readme for the simulations associated with:
Hojeong Kim, Impact of the localization of dendritic calcium persistent inward current on the input-output properties of spinal motoneuron pool: a computational study, J App Physiol 123(5):1166-1187, 2017.
The goal of this study is to investigate how the dendritic Ca-PIC location influences nonlinear input-output properties and depends on the type of motoneurons across the motoneuron pool. A model motoneuron pool consisting of 10 motoneurons was constructed using a recently developed two-compartment modeling approach that reflected key cell type-associated properties experimentally identified. The dendritic excitability and firing output depended systematically on both the PIC location and the motoneuron type. The PIC onset and offset in the current-voltage (I-V) relationship tended to occur at more hyperpolarized voltages as the path length to the PIC channels from the soma increased and as the cell type shifted from high- to low-threshold motoneurons. At the same time, the firing acceleration and frequency hysteresis in the frequency-current (F-I) relationship became faster and larger, respectively. However, the PIC onset-offset hysteresis increased as the path length and the recruitment threshold increased. Furthermore, the gain of frequency-current function before full PIC activation was larger for PIC channels located over distal dendritic regions in low- compared with high-threshold motoneurons. When compared with previously published experimental observations, the modeling concurred when Ca-PIC channels were placed closer to the soma in high- than low-threshold motoneurons in the model motoneuron pool. All of these results suggest that the negative relationship of Ca-PIC location and cell recruitment threshold may underlie the systematic variation in I-V and F-I transformation across the motoneuron pool.
The direct comparison between the anatomical and reduced motoneuron model has been made for FR-type alpha-motoneuron while varying the distance (i.e., Dpath) to the dendritic site of Ca-PIC from the soma in our previous study: 2014 PLOS ONE (Kim, Jones and Heckman). The input-output properties of the reduced motoneuron model presented in Figure 3 of the paper can be simulated by running individual ode files for Figure 3 A-D. The input-output properties for other types of reduced motoneurons over various locations of Ca-PIC in the dendrites can be simulated by varying the values of model parameters as specified in Table1.xls.
Convergence Research Institute