This is the readme for the modeling in the paper:

Ohura S, Kamiya H (2018) Sodium Channel-Dependent and -Independent Mechanisms Underlying Axonal Afterdepolarization at Mouse Hippocampal Mossy Fibers. eNeuro

whos model was the Hodgkin-Huxley type model of the set of sodium, potassium, and leakage channels found in the hippocampal mossy fiber boutons as described in

Engel D, Jonas P (2005) Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons. Neuron 45:405-17

This model was contributed by H Kamiya.

Two illustrations show the simulation configuration in which sodium and potassium conductance was omitted from the axon and the bouton compartments shown in red.

To run the simulations, follow these steps:

  1. compile the mod files using nrnivmodl under Mac OS X and Linux, or mknrndll under Windows
  2. run mosinit.hoc in NEURON. Clicking Init & Run button in RunControl panel performs the simulation of propagating action potentials along mossy fiber axons and plots the results using NEURON's graphical user interface.
  3. click radio buttons in the panel "passive_propagation" and click "Init & Run" in the RunControl panel to perform simulation shown in Figs. 4G and 4H.

Here are screenshots of pressing the successive buttons available in the GUI that is presented when you start the simulation:

screenshot 1 screenshot 2 screenshot 3 screenshot 4

Questions about this model should be directed to