Model files in the NEURON simulation environment (v8.0) from the paper

"Analysis of age-dependent alterations in excitability properties of CA1 pyramidal neurons in an APPPS1 model of Alzheimer's disease"

by Paola Vitale, Ana Rita Salgueiro-Pereira, Carmen Alina Lupascu, Rosanna Migliore, Michele Migliore and Helene Marie

Frontiers in Aging Neuroscience 2021

Usage:

� Compile the mod files with mknrndll (mswin or graphical mac) or nrnivmodl (unix/linux)).

� Start the simulation by (unix/linux) typing on the command line: nrngui Figure3D.hoc or (mac os x) drag and dropping the Figure3D.hoc file on the nrngui icon or (mswin) double clicking on the Figure3D.hoc file.

� After selecting the experimental trace (on ''exp'' panel) and the corresponding phenotype (on ''model'' panel), simulation will reproduce the traces in Figure 3D of the paper.

� To test more parameters the user should could also handling the ''values'' panel and perform his own simulation.

Example: clicking on "exp -0.15 WT-10m" and "WT-10m" and running the simulation the window should produce the following graph:

Questions on how to use this model should be directed to paola.vitale@ibf.cnr.it or to michele.migliore@cnr.it

All electrophysiological traces and morphologies used for the models are available at the Human Brain Project collab https://humanbrainproject.github.io/hbp-bsp-live-papers/2021/vitale_et_al_2021/vitale_et_al_2021.html

Access to this resource requires free user registration at https://www.humanbrainproject.eu/en/hbp-platforms/getting-access/