Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Excessive beta oscillations in Parkinson's disease (Pavlides et al. 2015)
Download zip file
Help downloading and running models
" ... Understanding the generation of beta oscillations is important to improve treatments for Parkinson’s disease. Competing theories exist for how these oscillations are generated in the affected brain circuits, which include the motor cortex and a set of subcortical nuclei called the basal ganglia. This paper suggests two hypotheses for the generation of beta oscillations. The first hypothesis is that beta oscillations are generated in the motor cortex, and the basal ganglia resonate to the cortical input. The second hypothesis additionally proposes that feedback from the basal ganglia to cortex is critically important for the presence of the oscillations. We show that the models can successfully account for a wide range of experimental data concerning the presence of beta oscillations in Parkinson’s disease."
Pavlides A, Hogan SJ, Bogacz R (2015) Computational Models Describing Possible Mechanisms for Generation of Excessive Beta Oscillations in Parkinson's Disease.
PLoS Comput Biol
(Click on a link to find other models with that property)
Pavlides, Alex ;
File not selected
<- Select file from this column.
Loading data, please wait...