Midbrain dopamine neuron: firing patterns (Canavier 1999)

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Accession:6763
Sodium dynamics drives the generation of slow oscillations postulated to underly NMDA-evoked bursting activity.
Reference:
1 . Canavier CC (1999) Sodium dynamics underlying burst firing and putative mechanisms for the regulation of the firing pattern in midbrain dopamine neurons: a computational approach. J Comput Neurosci 6:49-69 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Electrogenic pump;
Brain Region(s)/Organism:
Cell Type(s): Substantia nigra pars compacta DA cell;
Channel(s): Na/K pump;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Oscillations; Sodium pump;
Implementer(s): Canavier, CC;
Search NeuronDB for information about:  Substantia nigra pars compacta DA cell; NMDA; Na/K pump;
COMMENT
Since this is an electrode current, positive values of i depolarize the cell
and in the presence of the extracellular mechanism there will be a change
in vext since i is not a transmembrane current but a current injected
directly to the inside of the cell.
ENDCOMMENT

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
	POINT_PROCESS VClamp1
	RANGE vset, gain, i
	ELECTRODE_CURRENT i
}
UNITS {
	(nA) = (nanoamp)
}

PARAMETER {
	vset = -65  (mV)
	gain = 1 (nA/mV)
	dt  (ms)
        v (mV)
}
ASSIGNED { i (nA) }

BREAKPOINT {
		i = gain*(vset-v)
}

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