NeuronDB: Neuron Details

Piriform cortex anterior pyramidal layer II GLU cell

- - - OLFcx - OCant - PRINC - - - glu

Properties are:

Present

Absent

Input Receptors

Intrinsic Currents

Output Transmitters

Distal apical dendrite

Piriform cortex anterior interneuron superficial GABA cell -Axon terminal.Gaba	GabaB
GABA is the transmitter released from large superficial horizontal cells and small globular-soma cells which mediate feed-forward inhibition of the pyramidal neurons when activated by axon terminals of mitral/tufted cells in the lateral olfactory tract or association fibers from other pyramidal neurons (Haberly LB, 1997¹ ). pp385,389,393-395,407).
Olfactory bulb main mitral GLU cell -Axon terminal.Glutamate	AMPA
GLU is the primary excitatory transmitter of the afferent fiber terminal of mitral and tufted cells (Jung MW et al, 1990 [rat]² ). GLU acts on both AMPA and NMDA receptors (Jung MW et al, 1990 [rat]³ ).
Piriform cortex anterior interneuron superficial GABA cell -Axon terminal.Gaba	GabaA

Olfactory bulb main mitral GLU cell -Axon terminal.Glutamate	NMDA
GLU is the primary excitatory transmitter of the afferent fiber terminal of mitral and tufted cells (Jung MW et al, 1990 [rat]² ). GLU acts on both AMPA and NMDA receptors (Jung MW et al, 1990 [rat]³ ).

Middle apical dendrite

-Axon terminal.Glutamate	AMPA
GLU is the primary excitatory transmitter of association fiber terminals (Jung MW et al, 1990 [rat]² ).
-Axon terminal.Glutamate	NMDA
GLU is the primary excitatory transmitter of association fiber terminals (Jung MW et al, 1990 [rat]² ).

Proximal apical dendrite

Piriform cortex anterior interneuron deep layer GABA cell -Axon terminal.Gaba	GabaA

Piriform cortex anterior interneuron deep layer GABA cell -Axon terminal.Gaba	GabaB

Distal basal dendrite

-Axon terminal.Glutamate	AMPA

-Axon terminal.Glutamate	NMDA

Middle basal dendrite

-Axon terminal.Glutamate	AMPA

-Axon terminal.Glutamate	NMDA

Proximal basal dendrite

-Axon terminal.Glutamate	AMPA

-Axon terminal.Glutamate	NMDA

Soma

Piriform cortex anterior interneuron deep layer GABA cell -Axon terminal.Gaba	GabaA
Deep multipolar cells have GABA-containing terminals arranged in baskets around pyramidal cell bodies reviewed in Haberly 1998).
Piriform cortex anterior interneuron deep layer GABA cell -Axon terminal.Gaba	GabaB

I A
Steady-state inactivation curve is 10 mV more depolarized in SP cells in endopiriform nucleus. "Modelling analysis suggested that this difference is sufficient to explain the more depolarized membrane potential of deep cells, and results in a 2-fold decrease in latancy of the first spike evoked by depolarizing steps" (Banks MI et al, 1996 [rat]⁴ ). These factors may contribute to greater susceptibility of endopiriforn nucleus to epileptogenesis. Reviewed in (Haberly LB, 1997¹ ). p397.
I L high threshold
Reviewed in (Haberly LB, 1997¹ ). p396.
I T low threshold
Reviewed in (Haberly LB, 1997¹ ). p396.
I Na,p
May generate long delays contributing to temporal patterns (Ketchum and Haberly 1991); may play a role in epileptogenesis (Hoffman WH and Haberly LB, 1989 [rat]⁵ ). Reviewed in (Haberly LB, 1997¹ ). p396
I K,Ca
Substantial in most deep pyramidal and multipolar cells; generates hyperpolarizing potentials lasting several seconds; as I AHP contributes to rapid spike frequency adaptation; blocked by cholinergic agonists (Constanti A and Sim JA, 1987 [guinea-pig]⁶ ). see also Tseng and Haberly 1989b; reviewed in (Haberly LB, 1997¹ ). p397).
I M
Tonically active at rest; induces a sag in hyperpolarizing responses; blocked by ACh. (Constanti A and Galvan M, 1983 [guinea pig]⁷ ). see also Tseng and Haberly 1989b; reviewed in (Haberly LB, 1997¹ ). p395).
I K

I Na,t

I h
(Constanti A and Galvan M, 1983 [guinea pig]⁸ ). This current "may be of limited significance within the normal physiological range of potential and extracellular environment" (Haberly LB, 1997¹ ). p396).

Axon hillock

I K

I Na,t

Axon fiber

I Na,t

Axon terminal

I N

Glutamate

-Middle apical dendrite.NMDA

-Middle apical dendrite.AMPA

-Distal basal dendrite.AMPA

-Distal basal dendrite.NMDA

-Middle basal dendrite.NMDA

-Middle basal dendrite.AMPA

-Proximal basal dendrite.AMPA

-Proximal basal dendrite.NMDA

Olfactory bulb main interneuron granule MC GABA cell

-Soma.NMDA

Piriform cortex anterior interneuron deep layer GABA cell

-Distal equivalent dendrite.AMPA

-Distal equivalent dendrite.NMDA

Olfactory bulb main interneuron granule TC GABA cell

-Soma.NMDA

Olfactory pyramidal neuron middle dendritic region (Dam) and olfactory cortical interneuron and olfactory granule cell

Classical References: first publications on each compartmental property; search PubMed for complete list
1.	Haberly LB. (1997) Olfactory cortex Synaptic Organization Of The Brain, Shepherd GM, ed. .
2.	Jung MW, Larson J and Lynch G. (1990) Role of NMDA and non-NMDA receptors in synaptic transmission in rat piriform cortex. Exp Brain Res 82:451-5.
3.	Jung MW, Larson J and Lynch G. (1990) Long-term potentiation of monosynaptic EPSPs in rat piriform cortex in vitro. Synapse 6:279-83 [Journal] .
4.	Banks MI, Haberly LB and Jackson MB. (1996) Layer-specific properties of the transient K current (IA) in piriform cortex. J Neurosci 16:3862-76.
5.	Hoffman WH and Haberly LB. (1989) Bursting induces persistent all-or-none EPSPs by an NMDA-dependent process in piriform cortex. J Neurosci 9:206-15.
6.	Constanti A and Sim JA. (1987) Muscarinic receptors mediating suppression of the M-current in guinea-pig olfactory cortex neurones may be of the M2-subtype. Br J Pharmacol 90:3-5.
7.	Constanti A and Galvan M. (1983) M-current in voltage-clamped olfactory cortex neurones. Neurosci Lett 39:65-70.
8.	Constanti A and Galvan M. (1983) Fast inward-rectifying current accounts for anomalous rectification in olfactory cortex neurones. J Physiol 335:153-78.