Hippocampus CA1 interneuron oriens alveus GABA cell

- - HG - Hip - CA1 - INT - oriens alveus - - gaba
Properties are:  Present   Absent 
Input Receptors
Intrinsic Currents
Output Transmitters
Distal equivalent dendrite
Hippocampus CA1 pyramidal GLU cell
 -Axon terminal.Glutamate
AMPA
Middle equivalent dendrite
Hippocampus CA1 pyramidal GLU cell
 -Axon terminal.Glutamate
AMPA
Proximal equivalent dendrite
Hippocampus CA1 pyramidal GLU cell
 -Axon terminal.Glutamate
AMPA
I Na,t
Patch Clamp recordings revealed density levels are similar to that found in the soma, with slightly different kinetics (Martina M et al, 20001 ). A distinction was made between axon-bearing and axon-lacking dendrites.
I K
Activation curve was studied using patch clamp recordings (Martina M et al, 20001 ).
Soma
AMPA
NMDA
GabaA
I Na,t
Densities and kinetics were measured from patch clamp recordings (Martina M et al, 20001 ).
I K
These channels are assembled from subunits of the Kv3 family and are necessary for the fast spiking phenotype of O/A interneurons (Lien CC and Jonas P, 20032 ). Densities and kinetics were measured from patch clamp recordings (Martina M et al, 20001 ). Nucleated patches revealed a fast component highly sensitive to external 4-AP and TEA (~57% of total K+ current) and a slow component that was sensitive to high concentrations of TEA, but insensitive to 4-AP (~25% of total K+ current) (Lien CC et al, 20023 ).
I A
This current was measured in nucleated patches from O/A interneurons and found to be ~19% of the total potassium current (Lien CC et al, 20023 ).
I h
This current was studied using whole-cell and perforated patch-clamp in O/A interneurons (Maccaferri G and McBain CJ, 19964 ). It contributes to the spontaneous activity of these cells and to the tonic inhibition of CA1 pyramidal neurons in the hippocampus (Lupica CR et al, 20015 ).
I K,Ca
Indirect evidence for this current was found in O-A interneurons (Zhang L and McBain CJ, 19956 ).
Axon hillock
I Na,t
I K
Axon fiber
I Na,t
I K
Axon terminal
Gaba
Hippocampus CA1 pyramidal GLU cell
 -Distal apical dendrite.Gaba
 -Middle apical dendrite.GabaA
 -Middle apical dendrite.GabaB
 -Proximal apical dendrite.GabaB
 -Proximal apical dendrite.GabaA
 -Distal basal dendrite.GabaA
 -Distal basal dendrite.GabaB
 -Middle basal dendrite.GabaA
 -Middle basal dendrite.GabaB
 -Proximal basal dendrite.GabaB
 -Proximal basal dendrite.GabaA
 -Soma.GabaB
 -Soma.GabaA
 -Axon hillock.GabaA
 -Axon hillock.GabaB
CA1 pyramidal cell
I K
Classical References: first publications on each compartmental property; search PubMed for complete list
1.  Martina M, Vida I and Jonas P. (2000) Distal initiation and active propagation of action potentials in interneuron dendrites. Science 287:295-300.
2.  Lien CC and Jonas P. (2003) Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons. J Neurosci 23:2058-68.
3.  Lien CC, Martina M, Schultz JH, Ehmke H and Jonas P. (2002) Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. J Physiol 538:405-19.
4.  Maccaferri G and McBain CJ. (1996) The hyperpolarization-activated current (Ih) and its contribution to pacemaker activity in rat CA1 hippocampal stratum oriens-alveus interneurones. J Physiol 497 ( Pt 1):119-30.
5.  Lupica CR, Bell JA, Hoffman AF and Watson PL. (2001) Contribution of the hyperpolarization-activated current (I(h)) to membrane potential and GABA release in hippocampal interneurons. J Neurophysiol 86:261-8 [Journal] .
6.  Zhang L and McBain CJ. (1995) Potassium conductances underlying repolarization and after-hyperpolarization in rat CA1 hippocampal interneurones. J Physiol 488 ( Pt 3):661-72.